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A new prebiotic from germinated barley for nutraceutical
treatment of ulcerative colitis.
J Gastroenterol Hepatol. 2002 Aug;17(8):818-24.
Bamba T, Kanauchi O, Andoh A, Fujiyama Y.
Department of Internal Medicine, Shiga University of Medical Science, Japan.
A germinated barley foodstuff (GBF) containing glutamine-rich protein and
hemicellulose-rich fiber was made from brewer's spent grain, by physical
isolation. Our previous studies demonstrated that GBF supported maintenance of
epithelial cell populations, facilitated epithelial repair, and suppressed
epithelial nuclear factor kappaB-DNA-binding activity through generating
increased short-chain fatty acid (especially butyrate) production by luminal
microflora, which includes Bifidobacterium and Eubacterium, thereby preventing
experimental colonic injury. The fiber fraction also modulates stool water
content because of its high water-holding capacity. The patients with mild to
moderate active ulcerative colitis who had been unresponsive to or intolerant of
standard treatment received 20-30 g GBF, feeding daily in a non-randomized,
open-label fashion. At 4 weeks, this treatment resulted in a significant
clinical and endoscopic improvement. The improvement was associated with an
increase in stool butyrate concentrations. These results indicate that GBF
feeding is a potentially new, attractive prebiotic treatment in patients with
ulcerative colitis. The potency of GBF on modulating microflora, as well as the
high water-holding capacity, may play an important role in treatment and
prolongation of remission in ulcerative colitis.
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