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Aging
Reversibility: from Thymus Graft to Vegetable Extract Treatment - Application to
Cure an Age-associated Pathology.
Biogerontology. 2005;6(4):245-53.
Basso A, Rossolini G, Piantanelli A, Amici D, Calzuola I, Mancinelli L, Marsili
V, Gianfranceschi GL.
Center of Biochemistry, Gerontological Research Department (I.N.R.C.A.), Via
Birarelli 8, I-60121, Anc -ona, Italy,
Neonatal thymus graft and thymus calf extract (TME) in vivo treatment exert
similar corrective actions on different mouse age-related alterations. The aim
of the present paper is to investigate whether a vegetal extract, wheat sprout
extract (WESPRE), could mimic the thymus action on recovering age-related
alterations and if this extract can cure an age-associated pathology, the
cataract in dogs. Present experiments were carried out by using WESPRE and TME
in vivo in old mice to check their ability to recover the altered DNA synthesis
in hepatocyte primary cultures. Old mice treated with WESPRE and TME showed a
recovery of hepatocyte DNA synthesis levels when compared with the old untreated
ones. The increase of DNA and protein contents observed in aged animals is
reduced by WESPRE treatments to levels observed in young mice hepatocytes. We
measured also WESPRE phosphorylation activity by endogenous kinase: it was from
10 to 40 times higher with respect to wheat seeds. Old dogs were orally treated
for a month and the lens opacity analysed before and after the treatment.
Results showed a reduction from 25 to 40% of lens opacity. The efficacy of wheat
sprouts in the recovery of age-related alterations and in treating
age-associated pathologies could be due to the contemporary presence of small
regulatory acid peptides, a remarkable level of highly energetic phosphoric
radicals and antioxidant molecules, peculiarities that may be, to some extent,
related to the aging process regulation.
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