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Alfalfa saponins and alfalfa seeds. Dietary effects in
cholesterol-fed rabbits.
Atherosclerosis. 1980 Nov;37(3):433-8.
Malinow MR, McLaughlin P,
Stafford C, Livingston AL,
Kohler GO.
Since alfalfa meal prevents hypercholesterolemia and atherosclerosis in rabbits
and alfalfa saponins prevent the expected rise in cholesterolemia induced by
dietary cholesterol in monkeys, the experiments being reported here were
performed to determine whether alfalfa saponins affect atherogenesis in rabbits.
In addition, the effects of alfalfa seeds were studied. Cholesterol-feb rabbits
were randomly assigned to 3 groups: (a) control animals (N = 18); (b) animals
maintained on a diet containing 1.0 to 1.2% alfalfa saponins (N = 18); and (c)
animals maintained on a diet containing 40% alfalfa seeds (N = 17). Results
after a 4-month observation period demonstrated that alfalfa saponins and
alfalfa seeds reduce hypercholesterolemia, aortic sudanophilia, and the
concentration of cholesterol in aortic intima-plus-media and in the liver, but
do not induce changes in the hematocrit.
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