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Brewer's spent grain, serum lipids and fecal sterol excretion in human subjects
with ileostomies.
J Nutr. 1991 Jun;121(6):778-84.
Zhang JX, Lundin E, Andersson H, Bosaeus I, Dahlgren S, Hallmans G, Stenling R,
Aman P.
Department of Pathology, University of Umea, Sweden.
A crossover design studying lipid and apoprotein levels in serum and excretion
of sterol, nitrogen and fat in ileostomy effluent was performed in 10 subjects
fed diets with or without supplementation with brewer's spent grain, which is
the residue of barley after the brewing of beer. More cholesterol, nitrogen, fat
and energy were excreted in the ileostomy effluents when the subjects consumed a
brewer's spent grain supplemented, high fiber diet than when they consumed a low
fiber diet. No significant change was found in the daily net sterol excretion.
The six subjects with low daily excretion of bile acids (less than 1000 mg/24 h)
had increased cholesterol and net cholesterol and decreased bile acid excretion
per day, and lowered serum LDL-cholesterol and apoprotein B levels after
supplementation with brewer's spent grain. We propose that subjects with low
daily bile acid excretion are suitable models for studying the effect of dietary
changes on sterol excretion and serum lipid levels. Increased fecal cholesterol
excretion is suggested to be the primary mechanism for the serum LDL-cholesterol
lowering effect of brewer's spent grain.
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