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Cancer-protective
properties of high-selenium broccoli.
J Agric Food Chem 2001 May;49(5):2679-83
Finley JW, Ip C, Lisk DJ, Davis CD, Hintze KJ, Whanger PD.
Grand Forks Human Nutrition Research Center, Agricultural Research Service, U.S.
Department of Agriculture, P.O. Box 9034, Grand Forks, North Dakota 58203-9034,
USA.
Selenium (Se) from high-Se garlic reduces the incidence of chemically induced
mammary tumors, and Se from high-Se broccoli reduces colon cancer. However, the
ability of Se from high-Se broccoli to protect against mammary cancer has not
been tested. Also, the sprout form of broccoli contains many secondary plant
compounds that are known to reduce cancer risk, but the anticarcinogenic
activity of broccoli sprouts has not been investigated. The present studies
examined the ability of high-Se broccoli or high-Se broccoli sprouts to protect
against chemically induced mammary or colon cancer. In one experiment, Sprague--Dawley
rats that consumed diets containing 3.0 microg of Se/g supplied as high-Se
broccoli had significantly fewer mammary tumors than rats fed 0.1 microg of Se
as selenite with or without the addition of regular broccoli. In the second
experiment, Fisher F-344 rats fed 2.0 microg of Se/g of diet supplied as either
high-Se broccoli florets or high-Se broccoli sprouts had significantly fewer
aberrant colon crypts than rats fed 0.1 or 2 microg of Se/g of diet supplied as
selenite with or without the addition of low-Se broccoli. These data demonstrate
that the cancer-protective effect of Se in high-Se broccoli extends to mammary
cancer and the protective forms of broccoli against colon cancer include high-Se
broccoli sprouts.
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