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Chinese
cabbage extracts and sulforaphane can protect H2O2-induced inhibition of gap
junctional intercellular communication through the inactivation of ERK1/2 and
p38 MAP kinases.
J Agric Food Chem. 2005 Oct 19;53(21):8205-10.
Hwang JW, Park JS, Jo EH, Kim SJ, Yoon BS, Kim SH, Lee YS, Kang KS.
Laboratory of Stem Cell and Tumor Biology, Department of Veterinary Public
Health, College of Veterinary Medicine, Seoul National University, Seoul
151-742, Korea.
The cruciferous vegetables such as Chinese cabbages and broccoli are known to
have anticancer phytochemicals, and the consumption of cruciferous vegetables
has been proposed to protect against various cancers. The anticarcinogenic
properties of some Chinese cabbage extracts and sulforaphane glucosinolate (SFN)
were assessed by examining their ability to prevent the inhibition of gap
junctional intercellular communication (GJIC) induced by hydrogen peroxide
(H2O2) in WB-F344 normal rat liver epithelial cells. The cells were preincubated
with Chinese cabbage extracts and SFN for 24 h followed by cotreatment with
cells and H2O2 (750 microM) for 1 h. Chinese cabbage extracts and SFN prevented
the inhibition of GJIC and phosphorylation of gap junction protein connexin43
(Cx43) by H2O2 treatment. Chinese cabbage extracts and SFN were able to prevent
the inhibition of GJIC through the blocking of Cx43 phosphorylaton and
inactivation of ERK 1/2 and p38 MAP kinase. The results suggest that cruciferous
vegetables and their components, SFN, may exert the anticancer effect by
targeting the GJIC as a functional dietary chemopreventive agent.
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