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Determination of
lignans and isoflavonoids in human female plasma following dietary
supplementation.
J Endocrinol 1994 Aug;142(2):251-9
Morton MS, Wilcox G, Wahlqvist ML, Griffiths K.
Tenovus Cancer Research Centre, University of Wales College of Medicine, Heath
Park, Cardiff, UK.
Plasma levels of the lignans enterodiol and enterolactone, and also the
isoflavonic phyto-oestrogens daidzein, equol and genistein, are reported for
postmenopausal Australian women consuming a traditional diet supplemented with
linseed, soya flour or clover sprouts. Analysis was performed by gas
chromatography-mass spectrometry, after enzymatic hydrolysis and ion-exchange
chromatography. Following linseed supplementation, combined levels of
enterolactone and enterodiol reached 500 ng/ml, whereas after soya flour or
clover sprouts the respective concentrations of equol, daidzein and genistein
reached 43, 312 and 148 ng/ml. Not all subjects were able to produce equol from
daidzein. The possible relationship and role of these weak dietary oestrogens as
restraining factors in the development of hormone-dependent cancers in Asian
populations is discussed.
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