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Effect of
cruciferous vegetables on lung cancer in patients stratified by genetic status:
a mendelian randomisation approach.
Lancet.
2005 Oct 29-Nov 4;366(9496):1558-60.
Brennan P, Hsu CC, Moullan N, Szeszenia-Dabrowska
N, Lissowska J, Zaridze D, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L,
Janout V, Gemignani F, Chabrier A, Hall J, Hung RJ, Boffetta P, Canzian F.
International Agency for Research on Cancer, Lyon, France. brennan@iarc.fr
Whether consumption of cruciferous vegetables protects against lung cancer is
unclear, largely because of potential confounding factors. We therefore studied
the role of cruciferous vegetables in lung cancer after stratifying by GSTM1 and
GSTT1 status, two genes implicated in the elimination of isothiocyanates, the
likely chemopreventative compound. In 2141 cases and 2168 controls, weekly
consumption of cruciferous vegetables protected against lung cancer in those who
were GSTM1 null (odds ratio=0.67, 95% CI 0.49-0.91), GSTT1 null (0.63,
0.37-1.07), or both (0.28, 0.11-0.67). No protective effect was seen in people
who were both GSTM1 and GSTT1 positive (0.88, 0.65-1.21). Similar protective
results were noted for consumption of cabbage and a combination of broccoli and
brussels sprouts. These data provide strong evidence for a substantial
protective effect of cruciferous vegetable consumption on lung cancer.
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