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Effects of pre-germinated brown
rice on beta-amyloid protein-induced learning and memory deficits in mice.
Biol Pharm Bull. 2004 Jul;27(7):1041-5.
Mamiya T, Asanuma T, Kise M, Ito Y, Mizukuchi A, Aoto H, Ukai M.
Department of Chemical Pharmacology, Faculty of Pharmacy,
Meijo University, Nagoya, Japan.
We evaluated the effects of pre-germinated brown rice (hatsuga genmai, PGR) on
learning and memory and compared them with those of polished rice or cornstarch.
In mice that were fed pellets of polished rice or PGR for two weeks, the
learning ability in the Morris water maze test was significantly enhanced
compared with mice that were fed cornstarch pellets. In the Y-maze test, the
intake of food pellets for two weeks failed to affect spontaneous alternation
behavior. Beta-amyloid(25-35) (Abeta(25-35): 3 nmol/mouse, i.c.v.) protein
impaired spontaneous alternation behavior in mice that were fed pellets of
cornstarch or polished rice. In contrast, PGR pellets prevented the
Abeta(25-35)-induced impairment of spontaneous alternation behavior. These
results suggest that polished rice and PGR have facilitating effects on spatial
learning. In particular, it is surmised that Pre-germinated rice may prevent
Alzheimer's disease associated with Abeta.
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