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Germinated barley foodstuff increases fecal volume and butyrate production at
relatively low doses and relieves constipation in humans.
Int J Mol Med. 1998 Oct;2(4):445-450.
Kanauchi O, Mitsuyama K, Saiki T, Nakamura T, Hitomi Y, Bamba T, Araki Y,
Fujiyama Y.
Applied Bioresearch Center, Corporate Research and Development Division, Kirin
Brewery Co. Ltd., Takasaki, Gunma 370-1295, Japan.
Germinated barley foodstuff (GBF), derived from the aleurone layer, scutellum
and germ of germinated barley, contains a large quantity of fermentable dietary
fibers, especially hemicellulose. GBF was given to 9 healthy volunteers in a
dose of 9 g of GBF per day for 10 consecutive days, and subsequently 18 g of GBF
for another 10 days. As a control, no GBF was given for 3 days before
administration of GBF (control period). Fecal weight, water content and short
chain fatty acid content were measured before and during the last 3 days of each
experimental period. Feeding of GBF significantly increased the fecal butyrate
content as well as fecal weight at both dose-levels (9 and 18 g/day), compared
with those during the control period. Daily administration of 9 g GBF induced
the maximum level of defecation in humans. Relatively mild but chronic
constipated volunteers (n=16) were administered 9 g of GBF daily for 14 days. In
this experiment, the condition of defecation (frequency, volume) was estimated
by a questionnaire survey. GBF significantly improved defecation within a short
period without severe adverse effects. No major abnormalities in laboratory
findings were found in hematologic and urinary analyses. In conclusion, daily
administration of 9 g GBF was effective for improving defecation in healthy but
constipated humans. GBF is a highly safe and effective foodstuff for improving
defecation.
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