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Inhibition of CYP2E1 with
natural agents may be a feasible strategy for minimizing the hepatotoxicity of
ethanol.
Med Hypotheses 2001 Jan;56(1):8-11
McCarty MF.
Pantox Laboratories, San Diego, California 92109, USA.
CYP2E1, induced in hepatocytes by heavy consumption of ethanol and certain other
drugs, is a potent generator of superoxide, and is thereby thought to mediate
the gravest aspects of alcoholic hepatotoxicity. Certain drugs such as the
sedative chlormethiazole are effective inhibitors of CYP2E1, and may have
clinical potential in the treatment of alcoholics. A number of phytochemicals
can also potently inhibit CYP2E1 - most notably certain isothiocyanates found in
crucifera, such as sulforaphane and phenethylisothiocyanate. Preparation of
these compounds from crucifera seeds or sprouts should enable commercial
production of supplements that would protect the livers of social drinkers while
concurrently reducing risk for carcinogen-induced cancers.
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