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Preventive effects of germinated barley foodstuff on methotrexate-induced
enteritis in rats.
Int J Mol Med. 1998 Jun;1(6):961-6.
Kanauchi O, Mitsuyama K, Saiki T, Agata K, Nakamura T, Iwanaga T.
Applied Bioresearch Center, Corporate Research and Development Division, Kirin
Brewery Co. Ltd., Takasaki, Gunma 370-12, Japan.
The preventive effects of the dietary germinated barley foodstuff (GBF), which
increases the contents of protein, RNA and DNA in the intestinal mucosa of rats
on the mucosal damage and diarrhea were examined in a methotrexate (MTX)-induced
enteritis model in rats. Sprague-Dawley rats intraperitoneally injected with MTX
(10 mg/kg body weight) were used as an enteritis model. After consumption of
diets containing GBF, glutamine or a glutamine-rich stuff (gluten), mucosal
damage, contents of mucosal protein, RNA and DNA, myeloperoxidase (MPO)
activity, bacterial translocation and DNA synthetic activity in the small
intestine were assessed. GBF more effectively prevented diarrhea and mucosal
damages, and increased mucosal protein, DNA and RNA contents than glutamine or
gluten. The bacterial trans-location and elevation of MPO activity induced by
MTX were depressed only by the consumption of GBF. GBF has a potential as
therapeutic diet to decrease the adverse effects of anti-cancer chemotherapy.
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