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Role of the
nrf-2 gene in protection and repair of gastric mucosa against oxidative stress.
Inflammopharmacology.
2005;13(1):83-90.
Yanaka A, Zhang S, Tauchi M, Suzuki H, Shibahara T, Matsui H, Nakahara A, Tanaka
N, Yamamoto M.
Department of Gastroenterology, Institute of Clinical Medicine, University of
Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Department of
Endoscopy, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai,
Tsukuba, Ibaraki 305-8575, Japan.
Helicobacter pylori infection, as well as NSAIDs induce oxidative stress on
gastric mucosa, thereby causing mucosal damage and retarding mucosal repair.
Cells can survive against chronic oxidative stress by enhancing activities of
anti-oxidant enzymes, thereby protecting cells from DNA damage. Recent studies
have clearly shown that the gene encoding Nrf-2 (NF-E2 p45-related factor-2)
plays an important role in the induction of antioxidant enzymes against
oxidative stress. In this paper, we will describe the cellular mechanisms by
which the nrf-2 gene stimulates anti-oxidant enzyme activities during exposure
to oxidative stress. Secondly, we will also mention the beneficial effects of
sulforaphane, an isothiocyanate family which is abundantly included in broccoli
sprouts, on gastric mucosa. Sulforaphane stimulates nrf-2 gene-dependent
anti-oxidant enzyme activities, thereby protecting cells from oxidative injury.
Finally, we will state our perspective on the efficacy of sulforaphane in
protection and repair of gastric mucosa against oxidative stress during H.
pylori infection.
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