|
ISS
820 East 20th Street
Cookeville, TN 38501 USA
931 526 1106
Bob@sproutnet.com
中文版
En espaņol
| |
Sulforaphane
enhances aquaporin-4 expression and decreases cerebral edema following traumatic
brain injury.
J Neurosci Res. 2005 Nov
15;82(4):499-506.
Zhao J, Moore AN, Clifton
GL, Dash PK.
The Vivian L. Smith Center for Neurologic Research and Department of
Neurobiology and Anatomy, The University of Texas Medical School, Houston,
Texas.
Brain edema, the infiltration and accumulation of excess fluid causing an
increase in brain tissue volume, often leads to a rise in intracranial pressure
and is a key contributor to the morbidity and mortality associated with
traumatic brain injury (TBI). The cellular and molecular mechanisms
contributing to the development/resolution of TBI-associated brain edema are
poorly understood. Aquaporin-4 (AQP4) water channel is expressed at high levels
in brain astrocytes, and the bidirectional transport of water through these
channels is critical for the maintenance of brain water homeostasis. By using a
rodent injury model, we show that TBI decreased AQP4 level in the injury core
and modestly increased it in the penumbra region surrounding the core.
Postinjury administration of sulforaphane (SUL), an isothiocyanate present
in abundance in cruciferous vegetables such as broccoli, attenuated AQP4 loss in
the injury core and further increased AQP4 levels in the penumbra region
compared with injured animals receiving vehicle. These increases in AQP4 levels
were accompanied by a significant reduction in brain edema (assessed by
percentage water content) at 3 days postinjury. These findings suggest
that the reduction of brain edema in response to SUL administration could be
due, in part, to water clearance by AQP4 from the injured brain.
Note for ISS: Several crucifer sprouts
including broccoli sprouts are the most potent natural source of sulforaphane
currently known.
|
