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ISS
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Sulforaphane reduces infarct volume following focal cerebral ischemia in
rodents.
Neurosci Lett. 2005 Oct 15
Zhao J, Kobori N, Aronowski J, Dash PK.
Vivian L. Smith Center for Neurologic Research, Department of Neurobiology and
Anatomy, University of Texas Medical School, P.O. Box 20708, Houston, TX 77225,
USA.
Stroke is the third leading cause of death and disability in the United
States. As several biochemical mechanisms have been proposed to contribute
to stroke pathophysiology, treatments acting on multiple targets may be
desirable. Sulforaphane (SUL), a naturally occurring isothiocyanate
present in cruciferous vegetables, has been shown to induce the expression of
multiple NF-E2-related factor-2 (Nrf2) responsive genes. In the present study,
we demonstrate that systemically administered SUL can enter the brain as
determined by increased mRNA and protein levels of the Nrf2-responsive gene heme
oxygenase 1 (HO-1). Delayed administration (15min) of a single dose of SUL
significantly decreased cerebral infarct volume following focal ischemia,
suggesting a potential therapeutic value for this compound.
Note for ISS: Several crucifer sprouts
including broccoli sprouts are the most potent natural source of sulforaphane
currently known.
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