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Supplying Sprout Companies Throughout the World

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Research on Sprouts and their Effects on Wellness & Disease Prevention

The research below is so encouraging that it may change the way you view food.  There is research to indicate that a single ingestion of 2.5 ounces of broccoli sprouts inhibited prostrate cancer three to six hours after consumption, and that a single serving of broccoli sprouts inhibits HDAC activity in human colon, prostate, and breast cancer cells.  There is also evidence to  suggest that two ounces a day of broccoli or other crucifer sprouts may eradicate H pylori infection, (causes ulcers), in seven days.  Bone up on sprouts as nutraceuticals and send this link to your friends.

Index

Aging - Alfalfa, Broccoli and Wheat Sprouts

Alcohol-Induced Liver Disease - Brown Rice, Broccoli and other Crucifer Sprouts

Alzheimer's Disease - Brown Rice Sprouts

Animal Nutrition - Sprouted Grains

Arthritis - See Rheumatoid Arthritis

Asthma - Broccoli Sprouts

Atherosclerosis  - Alfalfa, Broccoli and other Crucifer Sprouts, Clover and Soybean Sprouts

Blood Pressure - Broccoli Sprouts

Bone Density - Alfalfa, Clover and Soybean Sprouts

Brain Hemorrhage - See Intracerebral Hemorrhage

Brain Inflammation - Broccoli and other Crucifer Sprouts

Cancer

Bladder Cancer - Broccoli and other Crucifer Sprouts

Brain Cancer - Broccoli and other Crucifer Sprouts

Breast Cancer & Mammary Tumors - Alfalfa, Broccoli and other Crucifer Sprouts, Clover, Mung Bean, Soybean and Watercress Sprouts

Cancer & Chemoprevention - General - Sprouts of: Alfalfa, Broccoli, Brussels Sprouts, Cauliflower, Chinese broccoli, Chinese Cabbage, Clover, Daikon, Garden Cress, Kale, Kohl Rabi, Mung Bean, Mustard, Radish, Red Cabbage, Rocket, Savoy Cabbage,  Soybean, Turnip, and Wasabi, Watercress, Wheat, White Cabbage, and White Radish.

Carcinogenesis - Broccoli Sprouts

Cervical Cancer - Sprouts of: Broccoli, Brussels Sprouts, Cabbage, Cauliflower, Daikon, Mung Bean, Radish and Soybean

Chemotherapy - Reducing the effects of Chemotherapy - Barley, Broccoli and other Crucifer Sprouts

Colon Cancer - Sprouts of Barley, Broccoli, Brussels sprouts, Buckwheat, Cabbage, Cauliflower, Daikon and Kale.

Endometrial Cancer - Sprouts of Broccoli, Brussels sprouts, Cabbage, Cauliflower, Daikon and Kale

Gastric Cancer - Broccoli Sprouts

Histone Deacetylase (HDAC) - Broccoli

Leukemia - Sprouts of Brown Rice, Broccoli, Brussels sprouts, Cabbage, Cauliflower, Daikon and Kale

Lung Cancer - Broccoli, Brussels Sprouts, Cabbage, Cauliflower, Mung Bean

Melanoma - also see Skin Cancer - Broccoli and other Crucifer Sprouts

Myeloid Malignancies - Broccoli and other Crucifer Sprouts

Ovarian Cancer - Broccoli and other Crucifer Sprouts

Pancreatic Cancer - Broccoli and other Crucifer Sprouts

Prostrate Cancer - Sprouts of: Alfalfa, Broccoli and other Crucifers, Clover,  Mung Bean, Soybean and Wheat.

Pulmonary Metastases - Broccoli and other Crucifer Sprouts

Rectal Cancer - Broccoli and other Crucifer Sprouts

Salivary Gland Adenoid Cystic Carcinoma - Broccoli and other Crucifer Sprouts

Skin Cancer - Broccoli and other Crucifer Sprouts

Stomach Cancer (also see H. Pylori) - Broccoli and other Crucifer Sprouts

Thyroid Cancer - Alfalfa Sprouts

Cardiovascular Disease - Alfalfa, Broccoli, Clover, Mung Bean, and Soybean Sprouts.

Cataracts - Wheat Sprouts

Central Nervous System Disorders - Broccoli and other Crucifer Sprouts

Cirrhosis of the Liver - See Alcohol Related Liver Disease

Choleresis - Daikon Sprouts

Cholesterol - Sprouts of: Alfalfa, Beet, Broccoli, Buckwheat, Cabbage, Daikon, Mung Bean, and Onion

Cochlear Degeneration - Broccoli and other Crucifer Sprouts

Coeliac Disease - Mung Bean Sprouts

Cognition - Broccoli and other Crucifer Sprouts

Colitis - Barley Sprouts

Constipation - Barley Sprouts

Coronary Artery Disease - Peanut Sprouts

Diabetes - Sprouts of: Barley,  C. moschata duchesne, Chick Pea, Daikon, Mucuna Prurines, Mung Bean, Rice, Soybean

Diarrhea - Barley Sprouts

Electrophilic Stress - Broccoli and other Crucifer Sprouts

Estrogen/Menopause Control - Sprouts of: Alfalfa, Beans, Broccoli and other Crucifer Sprouts, Clover, Mung Bean, Soybean

Flatulence - Mung Bean and Soybean Sprouts

Glioma - Broccoli and other Crucifer Sprouts

H. pylori, Ulcers and Gastritis - Broccoli and other Crucifer Sprouts

Heart Disease also see Arteriolosclerosis, Blood Pressure, Cardiovascular Disease, Cholesterol, Coronary Artery Disease and Hypertension - Alfalfa, Clover and Soybean Sprouts

Hyperglycemia - Broccoli and other Crucifer Sprouts

Hypertension also see Blood Pressure - Broccoli Sprouts

Inflammation & Inflammatory Disorders - Sprouts of: Alfalfa, Barley, Broccoli, Crucifers, Onion

Learning - Brown Rice Sprouts

Macular Degeneration - Broccoli Sprouts

Memory - Brown Rice Sprouts

Menopause - See Estrogen

Menstruation, Premenstrual Symptoms, and Post Menstrual Symptoms - Also see Estrogen - Soybean Sprouts

Muscle Damage - Broccoli and other Crucifer Sprouts

Mutagenesis - Broccoli Sprouts
Neurodegeneration - Alfalfa, Broccoli, Clover, Crucifers, and Soybean Sprouts

Osteoporosis - Alfalfa, Clover, Mung Bean, Soybean Sprouts

Oxidative Stress - Broccoli and other Crucifer Sprouts

Pathogenic Bacteria - Broccoli and other Crucifer Sprouts

Pregnancy - Broccoli Sprouts

Respiratory Illness - Broccoli and other Crucifer Sprouts

Retinal Light Damage - (Eye damage from light) - Broccoli Sprouts

Retinal Degeneration - Broccoli and other Crucifer Sprouts

Rheumatoid Arthritis - Broccoli and other Crucifer Sprouts

Scurvy - Many (about half of all) Sprouted Peas, Beans and Lentils

Stroke - Alfalfa, Broccoli, Clover, many Crucifers and Soybean Sprouts

Transplants - Broccoli and many other Crucifer Sprouts

Traumatic Brain Injury - Broccoli and many other Crucifer Sprouts

Ulcers - See H. Pylori

Vascular Disease - Barley Sprouts

Aging

"Aging Reversibility: from Thymus Graft to Vegetable Extract Treatment - Application to Cure an Age-associated Pathology"  Biogerontology. 2005;6(4):245-53. Basso A, Rossolini G, Piantanelli A, Amici D, Calzuola I, Mancinelli L, Marsili V, Gianfranceschi GL.

"Dietary approach to decrease aging-related CNS inflammation" Nutr Neurosci. 2005 Apr;8(2):101-10.Noyan-Ashraf MH, Sadeghinejad Z, Juurlink BH.

Dietary histone deacetylase inhibitors: From cells to mice to man. Semin Cancer Biol. 2007 May 5; Dashwood RH, Ho E. Linus Pauling Institute, Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.

"High-ORAC Foods May Slow Aging", Judy McBride, USDA ARS, February 8, 1999.

Alcohol-Induced Liver Disease

"Germinated Brown Rice Extract Shows a Nutraceutical Effect in the Recovery of Chronic Alcohol-Related Symptoms" Journal of Medicinal Food, Jul 2003, Vol. 6, No. 2: 115-121, Suk-Heung Oh, Ju-Ryoun Soh, MS; Youn-Soo Cha, PhD

"Inhibition of CYP2E1 with natural agents may be a feasible strategy for minimizing the hepatotoxicity of ethanol.", Med Hypotheses 2001 Jan;56(1):8-11, McCarty MF., Pantox Laboratories, San Diego, California 92109, USA.

Alzheimer's Disease

"Effects of pre-germinated brown rice on beta-amyloid protein-induced learning and memory deficits in mice"  Biol Pharm Bull. 2004 Jul;27(7):1041-5. Mamiya T, Asanuma T, Kise M, Ito Y, Mizukuchi A, Aoto H, Ukai M. Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.

"Nuclear factor erythroid 2-related factor 2 protects against beta amyloid" Katja Kanninen, Tarja M. Malm, Henna-Kaisa Jyrkkänen, Gundars Goldsteins, Velta Keksa-Goldsteine, Heikki Tanila, Masayuki Yamamoto, Seppo Ylä-Herttuala, Anna-Liisa Levonen b,c, Jari Koistinaho.

Animal Nutrition

"Commercial Hydroponic Fodder Growing in South Africa", D. A. Harris, Republic of South Africa, from the Proceedings of the Third International Congress of Soilless Culture, Sassari, Italy, 7-12 May 1973.

"Effect of Hydroponically Produced Oat Grass on Ration Digestibility of Cattle", R. J. Hillier and T. W. Perry, Purdue University, Lafayette, Indiana.

"Effect of various treatments on the nutritional value of rye or rye fractions" Br Poult Sci. 1988 Dec;29(4):709-20. Ward AT, Marquardt RR. Department of Animal Science, University of Manitoba, Winnipeg, Canada.

"Feeding Value of Hydroponically Sprouted Barley for Poultry and Pigs", D.J. Peer and S. Leeson, Department of Animal Science and Poultry Sciences, University of Guelph, Guelph, Onterio.

"Feeding Value of Sprouted Wheat (Triticum Aestivum) for Beef Cattle Finishing Diets", Animal Feed Science and Technology, 15 (1986) 113-121.

"Feeding Livestock form the Hydroponic Garden", Arizona State University, May 1974.

"Hydroponic Shed Produces enough feed for 55 cows", New Zealand Journal of Agriculture 1986, 151 : 11, 18-19.

"Malt sprouts as a source of supplemental protein for ruminants.", J Dairy Sci 1986 Nov;69(11):2959-62, Erickson PS, Murphy MR, Davis CL.

"Nutrient Content of Hydroponically Sprouted Barley", D. J. Peer and S. Leeson, Animal Feed Science and Technology, 13 (1985) 191-202.

"Nutritive Value of Hydroponic Feed and its use for Feeding High Yielding Cows."  Grigor' ev, Fitsev, and Lesnitskaya.  Article in Russian. Abstract in English.

"Nutritive Value of Sprouted Wheat for Swine and Poultry", R. C. Bull and C. F Petersen, University of Idaho, Moscow, Idaho.

"Production of Two Highly Active Bacterial Phytases with Broad pH Optima in Germinated Transgenic Rice Seeds", Transgenic Res. 2004 Feb;13(1):29-39. Hong CY, Cheng KJ, Tseng TH, Wang CS, Liu LF, Yu SM. Institute of Molecular Biology, Academia Sinica, Nankang, Taipei 11529, Taiwan, ROC.

Arthritis - See Rheumatoid Arthritis

Asthma

"Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway" Clin Immunol. 2008 Nov 21. Riedl MA, Saxon A, Diaz-Sanchez D.  The Hart and Louis Laboratory, Clinical Immunology and Allergy, Department of Medicine, UCLA David Geffen School of Medicine.

Atherosclerosis

Blood Pressure

"Dietary Approach to Attenuate Oxidative Stress, Hypertension, and Inflammation in the Cardiovascular System", Proceedings of the National Academy of Sciences of the United States of America, PNAS, May 4, 2004, vol. 101, no. 18, 7094-7099, Medical Sciences, Lingyun Wu , M. Hossein Noyan Ashraf*, Marina Facci, Rui Wang, Phyllis G. Paterson , Alison Ferrie and Bernhard H. J. Juurlink.

"Dietary approaches to positively influence fetal determinants of adult health" FASEB J. 2005 Dec 14; Noyan-Ashraf MH, Wu L, Wang R, Juurlink BH.

Bone Density

"Health effects of phytoestrogens" Forum Nutr. 2005;(57):100-11. Branca F, Lorenzetti S. National Institute for Research on Food and Nutrition, Rome, Italy.

Brain Hemorrhage - See Intracerebral Hemorrhage

Brain Inflammation

"The transcription factor Nrf2 is a therapeutic target against brain inflammation." J Immunol. 2008 Jul 1;181(1):680-9. Innamorato NG, Rojo AI, García-Yagüe AJ, Yamamoto M, de Ceballos ML, Cuadrado A. Departamento de Bioquímica e Instituto de Investigaciones Biomédicas Alberto Sols Consejo Superior de Investigaciones Científicas-Universidad Autónoma, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain.

Cancer

Bladder Cancer

"Broccoli sprout extracts inhibit bladder cancer cell proliferation" 2005 IFT Annual Meeting, July 15-20 - New Orleans, Louisiana, Session 54G, Nutraceutical & Functional Foods: General II, R. A. ROSSELOT1, S. K. Clinton2, S. J. Schwartz1, and Q. Tian3.

"Inhibition of Urinary Bladder Carcinogenesis by Broccoli Sprouts"  Cancer Res. 2008 Feb 29. Munday R, Mhawech-Fauceglia P, Munday CM, Paonessa JD, Tang L, Munday JS, Lister C, Wilson P, Fahey JW, Davis W, Zhang Y.

"Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract." Tang L, Zhang Y, Jobson HE, Li J, Stephenson KK, Wade KL, Fahey JW. Department of Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Science 711, Buffalo, NY 14263, USA.

 

"Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-kappaB-DNA-binding activity in human bladder T24 cells." Int J Oncol. 2009 Apr;34(4):1129-34. Shan Y, Wu K, Wang W, Wang S, Lin N, Zhao R, Cassidy A, Bao Y. School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK.

Brain Cancer

"Erucin, a new promising cancer chemopreventive agent from rocket salads, shows anti-proliferative activity on human lung carcinoma A549 cells." Food Chem Toxicol.  2009 Jul;47(7):1430-6. Epub 2009 Mar 27. Melchini A, Costa C, Traka M, Miceli N, Mithen R, De Pasquale R, Trovato A. Dip. Farmaco-Biologico, Facoltà di Farmacia, Università di Messina, Villaggio Annunziata, 98168 Messina, Italy.

Breast Cancer & Mammary Tumors

"Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells." Toxicol Appl Pharmacol. 2005 Jun 10; Rose P, Huang Q, Ong CN, Whiteman M.

 

"Cancer-protective properties of high-selenium broccoli." J Agric Food Chem 2001 May;49(5):2679-83, Finley JW, Ip C, Lisk DJ, Davis CD, Hintze KJ, Whanger PD., Grand Forks Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, P.O. Box 9034, Grand Forks, North Dakota 58203-9034, USA.

 

"Comparison of the effects of phenethyl isothiocyanate and sulforaphane on gene expression in breast cancer and normal mammary epithelial cells." Exp Biol Med (Maywood). 2009 Mar;234(3):287-95. Epub 2009 Jan 14. Telang U, Brazeau DA, Morris ME. Department of Pharmaceutical Sciences, 517 Hochstetter Hall, University at Buffalo, State University of New York, Amherst, NY 14260-1200, USA.

 

"Dietary patterns and breast cancer risk in the shanghai breast cancer study." Cancer Epidemiol Biomarkers Prev. 2007 Jul;16(7):1443-8. Epub 2007 Jul 10. Cui X, Dai Q, Tseng M, Shu XO, Gao YT, Zheng W. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.

"Evaluation of the estrogenic effects of legume extracts containing phytoestrogens." J Agric Food Chem. 2003 Apr 9;51(8):2193-9. Boue SM, Wiese TE, Nehls S, Burow ME, Elliott S, Carter-Wientjes CH, Shih BY, McLachlan JA, Cleveland TE. Agricultural Research Service, Southern Regional Research Center, U.S. Department of Agriculture, New Orleans, Louisiana 70179, USA.

"Food sources of phyto-oestrogens and their precursors in Europe", Br J Nutr. 2003 Jun;89 Suppl 1:S39-43. Fletcher RJ. Kellogg Company, Manchester, UK.

"Health effects of phytoestrogens" Forum Nutr. 2005;(57):100-11. Branca F, Lorenzetti S. National Institute for Research on Food and Nutrition, Rome, Italy.

"High-Selenium Broccoli Stymies Some Cancers", Science Update, Agricultural Research Magazine, April 2002.

"Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds." Environ Mol Mutagen. 2009 Feb 5. Nian H, Delage B, Ho E, Dashwood RH. Linus Pauling Institute, Oregon State University, Corvallis, Oregon.

"Modulation of markers associated with aggressive phenotype in MDA-MB-231 breast carcinoma cells by sulforaphane."  Neoplasma. 2009;56(6):548-56. Hunakova L, Sedlakova O, Cholujova D, Gronesova P, Duraj J, Sedlak J. Tumor Immunology Laboratory, Cancer Research Institute, Bratislava, Slovak Republic.

"Molecular Targets and Anticancer Potential of Indole-3-Carbinol and Its Derivatives" Cell Cycle. 2005 Sep 6;4(9), Aggarwal BB, Ichikawa H.

"Preclinical and Clinical Evaluation of Sulforaphane for Chemoprevention in the Breast" Carcinogenesis. 2007 Mar 7; Cornblatt BS, et al. Department of Environmental Health Sciences, The Johns Hopkins University, Baltimore, Maryland 21205.

"Regulation of estrogen receptor alpha expression in human breast cancer cells by sulforaphane." Ramirez MC, Singletary K. Department of Food Science and Human Nutrition, University of Illinois, Urbana, 61801, USA.

"Suppression of microtubule dynamic instability and turnover in MCF7 breast cancer cells by sulforaphane." Carcinogenesis. 2008 Dec;29(12):2360-8. Epub 2008 Oct 23. Azarenko O, Okouneva T, Singletary KW, Jordan MA, Wilson L. Department of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA.

"Vegetable extracts may aid breast cancer prevention" August 9, 2005, By Keith T. Mead, Special to The Clarion-Ledger.

Cancer & Chemoprevention - General

"Alkylperoxyl radical-scavenging activity of various flavonoids and other phenolic compounds: implications for the anti-tumor-promoter effect of vegetables.", J Agric Food Chem 1999 Feb;47(2):397-402, Sawa T, Nakao M, Akaike T, Ono K, Maeda H.Department of Microbiology, Kumamoto University School of Medicine, Japan.

"Anti-cancer Potential of Asian Brassicas" RIRDC Project No DAQ-307A, June 2004 - June 2007 Dr Tim O'Hare Queensland Department of Primary Industries and Fisheries, Queensland Horticulture Institute, Gatton Research Station.

"Anti-cancer Potential of Asian Brassicas, Glucosinolates & Chemoprevention"   A report for the Rural Industries Research and Development Corporation, by Tim O’Hare, Lesleigh Force, Lung Wong and Donald Irving, December 2006.

"Apigenin and cancer chemoprevention: Progress, potential and promise (Review)." Int J Oncol. 2007 Jan;30(1):233-45. Patel D, Shukla S, Gupta S.

 

"Broccoli sprouts in cancer prevention.", Nutr Rev 1998 Apr;56(4 Pt 1):127-30, Nestle M.

 

"Cancer Preventive Properties of Varieties of Brassica Oleracea: a Review", AM J Clin Nutrition 1994;59 pp. 1166-1170. Beecher, Christopher.

 

"Chinese cabbage extracts and sulforaphane can protect H2O2-induced inhibition of gap junctional intercellular communication through the inactivation of ERK1/2 and p38 MAP kinases." J Agric Food Chem. 2005 Oct 19;53(21):8205-10. Hwang JW, Park JS, Jo EH, Kim SJ, Yoon BS, Kim SH, Lee YS, Kang KS.

 

"Daikon, a promising anti-cancer vegetable" RIRDC Project No DAQ-342A, June 2007,  Dr Tim O'Hare Queensland Department of Primary Industries and Fisheries,

Queensland Horticulture Institute, Gatton Research Station.

 

Dietary histone deacetylase inhibitors: From cells to mice to man. Semin Cancer Biol. 2007 May 5; Dashwood RH, Ho E. Linus Pauling Institute, Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.

 

"Dietary phytoestrogens." Annu Rev Nutr 1997;17:353-81, Kurzer MS, Xu X., Department of Food Science and Nutrition, University of Minnesota, St. Paul 55108, USA.

"Effects of mustard sprouts and allylisothiocyanate on benzo(a)pyrene-induced DNA damage in human-derived cells: A model study with the single cell gel electrophoresis/Hep G2 assay.", Teratog Carcinog Mutagen 2003;23 Suppl 1:273-82, Uhl M, Laky B, Lhoste E, Kassie F, Kundi M, Knasmuller S., Insitute of Cancer Research, University of Vienna, Austria.

"Epidemiological studies on brassica vegetables and cancer risk." Cancer Epidemiol Biomarkers Prev. 1996 Sep;5(9):733-48. Verhoeven DT, Goldbohm RA, van Poppel G, Verhagen H, van den Brandt PA. Netherlands Organization for Applied Scientific Research, Nutrition and Food Research Institute, Zeist, The Netherlands.

"Evaporative light-scattering analysis of sulforaphane in broccoli samples: Quality of broccoli products regarding sulforaphane contents." J Agric Food Chem. 2006 Apr 5;54(7):2479-83. Nakagawa K, Umeda T, Higuchi O, Tsuzuki T, Suzuki T, Miyazawa T. Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.

"Glucosinolate Compostition and Anti-Cancer Potential of Daikon and Radish Sprouts" ISHS Acta Horticulturae 765: XXVII International Horticultural Congress - IHC2006: International Symposium on Plants as Food and Medicine: The Utilization and Development of Horticultural Plants for Human Health. T.J. O'Hare, L.S. Wong, L.E. Force, C.B. Gurung, D.E. Irving, D.J. Williams.

"Glucosinolate profiling of seed and sprouts of B. oleracea varieties used for food" Scientia Horticulturae, v.114(4):234-242, 2007. Bellostas, N.; Kachlicki, P.; Sorensen, J.C.; Sorensen, H.

 

"Glucosinolates in Brassica vegetables: The influence of the food supply chain on intake, bioavailability and human health".  Mol Nutr Food Res. 2008 Nov 26, Verkerk R, Schreiner M, Krumbein A, Ciska E, Holst B, Rowland I, De Schrijver R, Hansen M, Gerhäuser C, Mithen R, Dekker M.

"Health effects of phytoestrogens" Forum Nutr. 2005;(57):100-11. Branca F, Lorenzetti S. National Institute for Research on Food and Nutrition, Rome, Italy.

"Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity." Int J Cancer. 2005 Nov 10;117(3):356-62. Yoxall V, Kentish P, Coldham N, Kuhnert N, Sauer MJ, Ioannides C.

"Multi-targeted prevention of cancer by sulforaphane." Cancer Lett. 2008 Oct 8;269(2):291-304. Epub 2008 May 27. Clarke JD, Dashwood RH, Ho E. Department of Nutrition and Exercise Sciences, 117 Milam Hall, Oregon State University, Corvallis, OR 97331, USA.

"Natural Abundance Of L-Canavanine, An Active Anticancer Agent, in Alfalfa, Medicago Sativa", (L.)Pharmaceutical Biology, 2000, Vol.38, No.1, pp. 001-006, Gerald A. Rosenthal and Palesa Nkomo, University of Kentucky, Laboratory of Biochemical Ecology, Lexington, USA.

"Nutrition and cancer: a review of the evidence for an anti-cancer diet" Nutr J. 2004 Oct 20;3:19, Donaldson MS. Hallelujah Acres Foundation, 13553 Vantage Hwy, Ellensburg, WA 98926, USA.

"Phytoestrogen content of foods--a compendium of literature values.", Nutr Cancer 1996;26(2):123-48. Reinli K, Block G., Public Health Nutrition Program, University of California at Berkeley 94720, USA.

"Preparation of Selenium-enriched Sprouts and Identification of Their Selenium Species by High-performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry." Biosci Biotechnol Biochem. 2004 Jan;68(1):193-9. Sugihara S, Kondo M, Chihara Y, Yuji M, Hattori H, Yoshida M. Laboratory of Food and Nutritional Sciences, Department of Biotechnology, Faculty of Engineering, Kansai University.

"Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract." Tang L, Zhang Y, Jobson HE, Li J, Stephenson KK, Wade KL, Fahey JW. Department of Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Science 711, Buffalo, NY 14263, USA.

"Short acidic peptides isolated from wheat sprout chromatin and involved in the control of cell proliferation Characterization by infrared spectroscopy and mass spectrometry." Peptides. 2005 Jun 12; Calzuola I, Giavarini F, Sassi P, Angelis LD, Gianfranceschi GL, Marsili V. Dipartimento di Biologia Cellulare e Molecolare

"Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene." J Biochem Mol Toxicol. 2009 Jan;23(1):18-28. Skupinska K, Misiewicz-Krzeminska I, Stypulkowski R, Lubelska K, Kasprzycka-Guttman T. National Medicines Institute, Chelmska 30/34, Warsaw, Poland.

 

"Total Phenolics Level, Antioxidant Activities and Cytotoxicity of Young Sprouts of Some Traditional Korean Salad Plants". Plant Foods Hum Nutr. 2008 Nov 19. Chon SU, Heo BG, Park YS, Kim DK, Gorinstein S. EFARINET Co. Ltd., BI Center, Chosun University, Gwangju, 501-759, South Korea.

"Wheat sprout extract-induced apoptosis in human cancer cells by proteasomes modulation." Biochimie. 2009 Sep;91(9):1131-44. Epub 2009 Jun 13 Bonfili L, Amici M, Cecarini V, Cuccioloni M, Tacconi R, Angeletti M, Fioretti E, Keller JN, Eleuteri AM.

"Wheat sprout extract induces changes on 20S proteasomes functionality." Amici M, Bonfili L, Spina M, Cecarini V, Calzuola I, Marsili V, Angeletti M, Fioretti E, Tacconi R, Gianfranceschi GL, Eleuteri AM. University of Camerino, Department of Biology M.C.A., 62032 Camerino (MC), Italy.

Carcinogenesis

"Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.", Proc Natl Acad Sci U S A 1997 Sep 16;94(19):10367-72, Fahey JW, Zhang Y, Talalay P. Brassica Chemoprotection Laboratory and Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

 

"Broccoli Sprouts as Inducers of Carcinogen-Detoxifying Enzyme Systems: Clinical, Dietary, and Policy Implications", Proc. Natl. Acad. Sci. USA, Vol. 94, pp. 11149-11151, October 1997, Marion Nestle, Department of Nutrition and Food Studies, New York University, 35 West 4th Street, 10th Floor, New York, NY 10012-1172.

 

"Chemoprotection by sulforaphane: keep one eye beyond Keap1." Cancer Lett. 2006 Feb 28;233(2):208-18. Myzak MC, Dashwood RH. Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.

Cervical Cancer

"Effect of Protein Hydrolysates from Germinated Soybean on Cancerous Cells of the Human Cervix: An In Vitro Study." Plant Foods Hum Nutr. 2009 Aug 18. Mora-Escobedo R, Robles-Ramírez MD, Ramón-Gallegos E, Reza-Alemán R.

"Isoliquiritigenin induces G2 and M phase arrest by inducing DNA damage and by inhibiting the metaphase/anaphase transition" Cancer Lett. 2009 Jan 22. Park I, Park KK, Park JH, Chung WY. Oral Cancer Research Institute, Yonsei University College of Dentistry, Seoul 120-752, Republic of Korea.

 

"Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds." Environ Mol Mutagen. 2009 Feb 5. Nian H, Delage B, Ho E, Dashwood RH. Linus Pauling Institute, Oregon State University, Corvallis, Oregon.

"Molecular Targets and Anticancer Potential of Indole-3-Carbinol and Its Derivatives" Cell Cycle. 2005 Sep 6;4(9), Aggarwal BB, Ichikawa H.

"Multi-targeted prevention of cancer by sulforaphane." Cancer Lett. 2008 Oct 8;269(2):291-304. Epub 2008 May 27. Clarke JD, Dashwood RH, Ho E. Department of Nutrition and Exercise Sciences, 117 Milam Hall, Oregon State University, Corvallis, OR 97331, USA.

Chemotherapy - Reducing the effects of Chemotherapy

"Chemopreventive agent sulforaphane enhances radiosensitivity in human tumor cells." Int J Cancer. 2009 Sep 1;125(5):1205-11. Yu D, Sekine-Suzuki E, Xue L, Fujimori A, Kubota N, Okayasu R. Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage-ku, Chiba-shi, Japan.

"Preventive effects of germinated barley foodstuff on methotrexate-induced enteritis in rats" Int J Mol Med. 1998 Jun;1(6):961-6. Kanauchi O, Mitsuyama K, Saiki T, Agata K, Nakamura T, Iwanaga T.  Applied Bioresearch Center, Corporate Research and Development Division, Kirin Brewery Co. Ltd., Takasaki, Gunma 370-12, Japan.

Colon Cancer

"Activation of several concurrent proapoptic pathways by sulforaphane in human colon cancer cells SW620." Food Chem Toxicol. 2009 Sep;47(9):2366-73. Epub 2009 Jun 27. Rudolf E, Andelová H, Cervinka M. Department of Medical Biology and Genetics, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Simkova 870, Hradec Kralove, Czech Republic.

 

"Anti-Inflammatory Effect of Buckwheat Sprouts in Lipopolysaccharide-Activated Human Colon Cancer Cells and Mice" Biosci Biotechnol Biochem. 2008 Dec 7. Ishii S, Katsumura T, Shiozuka C, Ooyauchi K, Kawasaki K, Takigawa S, Fukushima T, Tokuji Y, Kinoshita M, Ohnishi M, Kawahara M, Ohba K. Department of Agricultural and Life Sciences, Obihiro University of Agriculture and Veterinary Medicine.

 

"Cancer-protective properties of high-selenium broccoli.", J Agric Food Chem 2001 May;49(5):2679-83, Finley JW, Ip C, Lisk DJ, Davis CD, Hintze KJ, Whanger PD., Grand Forks Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, P.O. Box 9034, Grand Forks, North Dakota 58203-9034, USA.

"Cytotoxic and Antioxidant Activity of 4-Methylthio-3-butenyl Isothiocyanate from Raphanus sativus L. (Kaiware Daikon) Sprouts" J. Agric. Food Chem., 56 (3), 875–883, 2008. 10.1021/jf073123c. Alessio Papi, Marina Orlandi, Giovanna Bartolini, Jessica Barillari, Renato Iori, Moreno Paolini, Fiammetta Ferroni, Maria Grazia Fumo, Gian Franco Pedulli, and Luca Valgimigli.

Dietary histone deacetylase inhibitors: From cells to mice to man. Semin Cancer Biol. 2007 May 5; Dashwood RH, Ho E. Linus Pauling Institute, Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.

"Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention." J Nutr. 2009 Dec;139(12):2393-6. Epub 2009 Oct 7. Ho E, Clarke JD, Dashwood RH. Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis OR 97331, USA.

"Effect of Cruciferous and Leguminous Sprouts on Genotoxicity, in Vitro and in Vivo". Cancer Epidemiol Biomarkers Prev. 2004 Jul;13(7):1199-205. Gill CI, Haldar S, Porter S, Matthews S, Sullivan S, Coulter J, McGlynn H, Rowland I., Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, United Kingdom.

"Effect of vegetable and carotenoid consumption on aberrant crypt multiplicity, a surrogate end-point marker for colorectal cancer in azoxymethane-induced rats", Carcinogenesis, Vol. 20, No. 12, 2267-2272, December 1999, Philip J. Rijken, Wim G. Timmer, Aart J. van de Kooij, Ingrid M. van Benschop, Sheila A. Wiseman, Michiel Meijers and Lilian B.M. Tijburg, Unilever Research Vlaardingen, PO Box 114, 3130 AC, Vlaardingen, The Netherlands.

"Epidemiological studies on brassica vegetables and cancer risk." Cancer Epidemiol Biomarkers Prev. 1996 Sep;5(9):733-48. Verhoeven DT, Goldbohm RA, van Poppel G, Verhagen H, van den Brandt PA. Netherlands Organization for Applied Scientific Research, Nutrition and Food Research Institute, Zeist, The Netherlands.

"Evaluation of Nutritional Availability and Anti-Tumor Activity of Selenium Contained in Selenium-Enriched Kaiware Radish Sprouts"  Biosci Biotechnol Biochem. 2007 Sep 7;  Yoshida M, Okada T, Namikawa Y, Matsuzaki Y, Nishiyama T, Fukunaga K. Laboratory of Food and Nutritional Sciences, Department of Biotechnology, Faculty of Engineering, Kansai University.

"High-Selenium Broccoli Stymies Some Cancers", Science Update, Agricultural Research Magazine, April 2002.

"Increased growth of Bifidobacterium and Eubacterium by germinated barley foodstuff, accompanied by enhanced butyrate production in healthy volunteers" Int J Mol Med. 1999 Feb;3(2):175-9. Kanauchi O, Fujiyama Y, Mitsuyama K, Araki Y, Ishii T, Nakamura T, Hitomi Y, Agata K, Saiki T, Andoh A, Toyonaga A, Bamba T. Applied Bioresearch Center, Corporate Research and Development Division, Kirin Brewery Co. Ltd., Takasaki, Gunma 370-12, Japan.

"Inhibition of Autophagy Potentiates Sulforaphane-Induced Apoptosis in Human Colon Cancer Cells." Ann Surg Oncol. 2009 Oct 15. Nishikawa T, Tsuno NH, Okaji Y, Shuno Y, Sasaki K, Hongo K, Sunami E, Kitayama J, Takahashi K, Nagawa H. Department of Surgical Oncology, Faculty of Medical Science, The University of Tokyo, Tokyo, Japan.

 

"Kaiware Daikon (Raphanus sativus L.) extract: a naturally multipotent chemopreventive agent." J Agric Food Chem. 2008 Sep 10;56(17):7823-30. Epub 2008 Jul 30. Barillari J, Iori R, Papi A, Orlandi M, Bartolini G, Gabbanini S, Pedulli GF, Valgimigli L. Consiglio per la Ricerca e la Sperimentazione in Agricoltura, Centro di Ricerca per le Colture Industriali (CRA-CIN), via di Corticella 133, 4129 Bologna, Italy.

 

"Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds." Environ Mol Mutagen. 2009 Feb 5. Nian H, Delage B, Ho E, Dashwood RH. Linus Pauling Institute, Oregon State University, Corvallis, Oregon.

"Molecular Targets and Anticancer Potential of Indole-3-Carbinol and Its Derivatives" Cell Cycle. 2005 Sep 6;4(9), Aggarwal BB, Ichikawa H.

“Preventive Effects of Powdered Broccoli Sprout on Azoxymethane-induced Rat Colonic Aberrant Crypt Foci”  J Toxicol Pathol 2004; 17: 119-126Suzuki, Kohno, Sugie, Okada, and Tanaka.

Endometrial Cancer

"Epidemiological studies on brassica vegetables and cancer risk." Cancer Epidemiol Biomarkers Prev. 1996 Sep;5(9):733-48. Verhoeven DT, Goldbohm RA, van Poppel G, Verhagen H, van den Brandt PA. Netherlands Organization for Applied Scientific Research, Nutrition and Food Research Institute, Zeist, The Netherlands.

"Molecular Targets and Anticancer Potential of Indole-3-Carbinol and Its Derivatives" Cell Cycle. 2005 Sep 6;4(9), Aggarwal BB, Ichikawa H.

Gastric Cancer

"Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans." Cancer Prev Res (Phila Pa). 2009 Apr;2(4):353-60. Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, Zhang S, Tauchi M, Suzuki H, Hyodo I, Yamamoto M., Division of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba-Ken, Tokyo, Japan.

 

"Role of glucoraphanin/sulfurophane from broccoli and broccoli sprouts in protection against cancer and other oxidative and degenerative diseases" 2005 IFT Annual Meeting, July 15-20 - New Orleans, Louisiana, Session 45, Health benefits of fruits and vegetables: Biological activity of phytonutrients, J. W. Fahey

"Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.", Proc Natl Acad Sci U S A 2002 May 28;99(11):7610-5, Fahey JW, Haristoy X, Dolan PM, Kensler TW, Scholtus I, Stephenson KK, Talalay P, Lozniewski A., Lewis B. and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205-2185, USA.

Histone Deacetylase (HDAC)

"A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase."  Cancer Res. 2004 Aug 15;64(16):5767-74. Myzak MC, Karplus PA, Chung FL, Dashwood RH.  Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA.

 

"Chemoprotection by sulforaphane: keep one eye beyond Keap1." Cancer Lett. 2006 Feb 28;233(2):208-18. Myzak MC, Dashwood RH. Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.

 

Dietary histone deacetylase inhibitors: From cells to mice to man. Semin Cancer Biol. 2007 May 5; Dashwood RH, Ho E. Linus Pauling Institute, Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.

Leukemia

"Effects of Germinated Brown Rice Extracts with Enhanced Levels of GABA on Cancer Cell Proliferation and Apoptosis Journal of Medicinal Food"  Apr 2004, Vol. 7, No. 1: 19-23, Chan-Ho Oh, Suk-Heung Oh; Department of Biotechnology, Woosuk University, Jeonju , Korea.

"Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds." Environ Mol Mutagen. 2009 Feb 5. Nian H, Delage B, Ho E, Dashwood RH. Linus Pauling Institute, Oregon State University, Corvallis, Oregon.

"Molecular Targets and Anticancer Potential of Indole-3-Carbinol and Its Derivatives" Cell Cycle. 2005 Sep 6;4(9), Aggarwal BB, Ichikawa H.

"Sulforaphane and 2-oxohexyl isothiocyanate induce cell growth arrest and apoptosis in L-1210 leukemia and ME-18 melanoma cells", Oncol Rep. 2003 Nov-Dec;10(6):2045-50. Misiewicz I, Skupinska K, Kasprzycka-Guttman T. Confocal Microscopy Laboratory, National Institute of Public Health, 00-725 Warsaw, Chelmska 30/34, Poland.

Lung Cancer

"Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach." Lancet. 2005 Oct 29-Nov 4;366(9496):1558-60.  Brennan P, Hsu CC, Moullan N, Szeszenia-Dabrowska N, Lissowska J, Zaridze D, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Gemignani F, Chabrier A, Hall J, Hung RJ, Boffetta P, Canzian F.

"Epidemiological studies on brassica vegetables and cancer risk." Cancer Epidemiol Biomarkers Prev. 1996 Sep;5(9):733-48. Verhoeven DT, Goldbohm RA, van Poppel G, Verhagen H, van den Brandt PA. Netherlands Organization for Applied Scientific Research, Nutrition and Food Research Institute, Zeist, The Netherlands.

"Induction of Cell Cycle Arrest and p21CIP1/WAF1 Expression in Human Lung Cancer Cells by Isoliquiritigenin", Cancer Letters, Volume 207, Issue 1 , 15 April 2004, Pages 27-35, Tsunehiro Ii, Yoshiko Satomi, Daishiro Katoh, Junichi Shimada, Masaki Baba, Toru Okuyama, Hoyoku Nishino and Nobuo Kitamura.

"Sulforaphane Induces Cell-Cycle Arrest and Apoptosis in Cultured Human Lung Adenocarcinoma LTEP-A2 Cells and Retards Growth of LTEP-A2 Xenografts in Vivo." J Nat Prod. 2008 Oct 15. Liang H, Lai B, Yuan Q.

"Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells." Cancer Res. 2009 Mar 1;69(5):2117-25. Epub 2009 Feb 17. Singh SV, Warin R, Xiao D, Powolny AA, Stan SD, Arlotti JA, Zeng Y, Hahm ER, Marynowski SW, Bommareddy A, Desai D, Amin S, Parise RA, Beumer JH, Chambers WH. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, USA.

Melanoma - also see Skin Cancer

"Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy." Int J Pharm. 2009 Nov 14. Do DP, Pai SB, Rizvi SA, D'Souza MJ. Department of Pharmaceutical Sciences, School of Pharmacy, Lake Erie College of Osteopathic Medicine (LECOM), 1858 W. Grandview Blvd., Erie, PA 16509, USA.

"Sulforaphane and 2-oxohexyl isothiocyanate induce cell growth arrest and apoptosis in L-1210 leukemia and ME-18 melanoma cells", Oncol Rep. 2003 Nov-Dec;10(6):2045-50. Misiewicz I, Skupinska K, Kasprzycka-Guttman T. Confocal Microscopy Laboratory, National Institute of Public Health, 00-725 Warsaw, Chelmska 30/34, Poland.

Myeloid Malignancies

"Enhancement of arsenic trioxide cytotoxicity by dietary isothiocyanates in human leukemic cells via a reactive oxygen species-dependent mechanism." Leuk Res. 2009 Jun 18. Doudican NA, Bowling B, Orlow SJ. NYU School of Medicine, Departments of Dermatology and Cell Biology, New York, NY, United States.

Ovarian Cancer

"Epidemiological studies on brassica vegetables and cancer risk." Cancer Epidemiol Biomarkers Prev. 1996 Sep;5(9):733-48. Verhoeven DT, Goldbohm RA, van Poppel G, Verhagen H, van den Brandt PA. Netherlands Organization for Applied Scientific Research, Nutrition and Food Research Institute, Zeist, The Netherlands.

Pancreatic Cancer

"Dietary agent, benzyl isothiocyanate inhibits signal transducer and activator of transcription 3 phosphorylation and collaborates with sulforaphane in the growth suppression of PANC-1 cancer cells." Cancer Cell Int. 2009 Aug 27;9:24. Hutzen B, Willis W, Jones S, Cen L, Deangelis S, Fuh B, Lin J. Department of Pediatrics, The Research Institute at Nationwide Childrens' Hospital, Columbus, OH, USA.

 

"Stress-associated hormone, norepinephrine, increases proliferation and IL-6 levels of human pancreatic duct epithelial cells and can be inhibited by the dietary agent, sulforaphane." Int J Oncol. 2008 Aug;33(2):415-9. Chan C, Lin HJ, Lin J.

 

"Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling." Gut. 2009 Jul;58(7):949-63. Epub 2008 Oct 1. Kallifatidis G, Rausch V, Baumann B, Apel A, Beckermann BM, Groth A, Mattern J, Li Z, Kolb A, Moldenhauer G, Altevogt P, Wirth T, Werner J, Schemmer P, Büchler MW, Salnikov AV, Herr I. Molecular OncoSurgery Group, University of Heidelberg and German Cancer Research Center, Heidelberg, Germany.

Prostrate Cancer

"Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate." PLoS One. 2008 Jul 2;3(7):e2568. Traka M, Gasper AV, Melchini A, Bacon JR, Needs PW, Frost V, Chantry A, Jones AM, Ortori CA, Barrett DA, Ball RY, Mills RD, Mithen RF. Phytochemicals and Health Programme, Institute of Food Research, Norwich Research Park, Norwich, United Kingdom.

 

Dietary histone deacetylase inhibitors: From cells to mice to man. Semin Cancer Biol. 2007 May 5; Dashwood RH, Ho E. Linus Pauling Institute, Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.

"Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention." J Nutr. 2009 Dec;139(12):2393-6. Epub 2009 Oct 7. Ho E, Clarke JD, Dashwood RH. Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis OR 97331, USA.

"Epidemiological studies on brassica vegetables and cancer risk." Cancer Epidemiol Biomarkers Prev. 1996 Sep;5(9):733-48. Verhoeven DT, Goldbohm RA, van Poppel G, Verhagen H, van den Brandt PA. Netherlands Organization for Applied Scientific Research, Nutrition and Food Research Institute, Zeist, The Netherlands.

"ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells." Carcinogenesis. 2005 Nov 4, Xu C, Shen G, Yuan X, Kim JH, Gopalkrishnan A, Keum YS, Nair S, Kong AN.

"Feeding Tomato and Broccoli Powders Enriched with Bioactives Improves Bioactivity Markers in Rats" J Agric Food Chem. 2009 Aug 3. Liu AG, Volker SE, Jeffery EH, Erdman JW.

"Health effects of phytoestrogens" Forum Nutr. 2005;(57):100-11. Branca F, Lorenzetti S. National Institute for Research on Food and Nutrition, Rome, Italy.

"Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells", Cancer. 2003 Dec 1;98(11):2511-20. Zhang J, Hsu B A JC, Kinseth B A MA, Bjeldanes LF, Firestone GL. Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720-3200, USA.

"Induction of cell cycle arrest in prostate cancer cells by the dietary compound isoliquiritigenin" J Med Food. 2009 Feb;12(1):8-14, Lee YM, Lim do Y, Choi HJ, Jung JI, Chung WY, Park JH.

"Isoliquiritigenin induces apoptosis by depolarizing mitochondrial membranes in prostate cancer cells." J Nutr Biochem. 2005 Dec 9; [Epub ahead of print], Jung JI, Lim SS, Choi HJ, Cho HJ, Shin HK, Kim EJ, Chung WY, Park KK, Park JH., Department of Food Science and Nutrition, Hallym University, Chuncheon 200-702, South Korea.

Isoliquiritigenin (ISL) inhibits ErbB3 signaling in prostate cancer cells. Biofactors. 2006;28(3-4):159-68. Jung JI, Chung E, Seon MR, Shin HK, Kim EJ, Lim SS, Chung WY, Park KK, Park JH. Department of Food Science and Nutrition and Silver Biotechnology Research Center, Hallym University, Chuncheon, Korea.

"Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling." J Nutr Biochem. 2008 Sep 26. Kwon GT, Cho HJ, Chung WY, Park KK, Moon A, Park JH. Department of Food Science and Nutrition, Hallym University, Chuncheon, 200-702, South Korea.

 

"Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds." Environ Mol Mutagen. 2009 Feb 5. Nian H, Delage B, Ho E, Dashwood RH. Linus Pauling Institute, Oregon State University, Corvallis, Oregon.

"Molecular Targets and Anticancer Potential of Indole-3-Carbinol and Its Derivatives" Cell Cycle. 2005 Sep 6;4(9), Aggarwal BB, Ichikawa H.

"Multi-targeted prevention of cancer by sulforaphane." Cancer Lett. 2008 Oct 8;269(2):291-304. Epub 2008 May 27. Clarke JD, Dashwood RH, Ho E. Department of Nutrition and Exercise Sciences, 117 Milam Hall, Oregon State University, Corvallis, OR 97331, USA.

"Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway." Pharm Res. 2009 Oct;26(10):2324-31. Keum YS, Khor TO, Lin W, Shen G, Kwon KH, Barve A, Li W, Kong AN.

"Potent induction of phase 2 enzymes in human prostate cells by sulforaphane.", Cancer Epidemiol Biomarkers Prev 2001 Sep;10(9):949-54, Brooks JD, Paton VG, Vidanes G., Department of Urology, Stanford University Medical Center, Stanford, California 94305-5118, USA.

"Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells." BMC Cancer. 2009 Nov 30;9:414. Abdulah R, Faried A, Kobayashi K, Yamazaki C, Suradji EW, Ito K, Suzuki K, Murakami M, Kuwano H, Koyama H. Department of Public Health, Gunma University Graduate School of Medicine, Japan.

"Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6." Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16663-8. Epub 2009 Sep 15. Gibbs A, Schwartzman J, Deng V, Alumkal J. Division of Hematology and Oncology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.

"Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP, and PC-3 prostate epithelial cells" Carcinogenesis. 2005 Nov 9. Myzak MC, Hardin K, Wang R, Dashwood RH, Ho E. Linus Pauling Institute, Oregon State University, Corvallis, OR 97331; Molecular and Cellular Biology Program, Oregon State University, Corvallis, OR 97331.

"Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells." Cancer Res. 2009 Mar 1;69(5):2117-25. Epub 2009 Feb 17. Singh SV, Warin R, Xiao D, Powolny AA, Stan SD, Arlotti JA, Zeng Y, Hahm ER, Marynowski SW, Bommareddy A, Desai D, Amin S, Parise RA, Beumer JH, Chambers WH. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, USA.

 

"Temporal changes in gene expression induced by sulforaphane in human prostate cancer cells" Prostate. 2008 Oct 30. Bhamre S, Sahoo D, Tibshirani R, Dill DL, Brooks JD. Department of Urology, Stanford University, Stanford, California.

"Wheat sprout extract induces changes on 20S proteasomes functionality." Amici M, Bonfili L, Spina M, Cecarini V, Calzuola I, Marsili V, Angeletti M, Fioretti E, Tacconi R, Gianfranceschi GL, Eleuteri AM. University of Camerino, Department of Biology M.C.A., 62032 Camerino (MC), Italy.

Pulmonary Metastases

"Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells." Cancer Res. 2009 Mar 1;69(5):2117-25. Epub 2009 Feb 17. Singh SV, Warin R, Xiao D, Powolny AA, Stan SD, Arlotti JA, Zeng Y, Hahm ER, Marynowski SW, Bommareddy A, Desai D, Amin S, Parise RA, Beumer JH, Chambers WH. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, USA.

"Modulation of rat pulmonary carcinogen-metabolising enzyme systems by the isothiocyanates erucin and sulforaphane." Chem Biol Interact. 2009 Jan 27;177(2):115-20. Epub 2008 Sep 7. Hanlon N, Coldham N, Sauer MJ, Ioannides C. Centre of Toxicology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK.

Rectal Cancer

"Epidemiological studies on brassica vegetables and cancer risk." Cancer Epidemiol Biomarkers Prev. 1996 Sep;5(9):733-48. Verhoeven DT, Goldbohm RA, van Poppel G, Verhagen H, van den Brandt PA. Netherlands Organization for Applied Scientific Research, Nutrition and Food Research Institute, Zeist, The Netherlands.

Salivary Gland Adenoid Cystic Carcinoma

"Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma."  Oral Oncol. 2009 Nov;45(11):998-1004. Epub 2009 Jul 8. Chu WF, Wu DM, Liu W, Wu LJ, Li DZ, Xu DY, Wang XF. Department of Pharmacology, Harbin Medical University, Baojian Road 157, Harbin, Heilongjiang 150081, PR China.

 

"Synergistic inhibitory effect of sulforaphane and 5-fluorouracil in high and low metastasis cell lines of salivary gland adenoid cystic carcinoma." Phytother Res. 2009 Mar;23(3):303-7. Wang XF, Wu DM, Li BX, Lu YJ, Yang BF. Department of Oral and Maxillofacial Surgery, the Second Affiliated Hospital of Harbin Medical University, PR China.

Skin Cancer

Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts. Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):847-51. Dinkova-Kostova AT, et.al. Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA.

"Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer." Cancer Res. 2009 Sep 1;69(17):7103-10. Epub 2009 Aug 11. Dickinson SE, Melton TF, Olson ER, Zhang J, Saboda K, Bowden GT. Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA.

"Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts." Cancer Lett. 2005 Nov 2; Dinkova-Kostova AT, Jenkins SN, Fahey JW, Ye L, Wehage SL, Liby KT, Stephenson KK, Wade KL, Talalay P.

"Sulforaphane and 2-oxohexyl isothiocyanate induce cell growth arrest and apoptosis in L-1210 leukemia and ME-18 melanoma cells", Oncol Rep. 2003 Nov-Dec;10(6):2045-50. Misiewicz I, Skupinska K, Kasprzycka-Guttman T. Confocal Microscopy Laboratory, National Institute of Public Health, 00-725 Warsaw, Chelmska 30/34, Poland.

"Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation" Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17500-17505. Talalay P, Fahey JW, Healy ZR, Wehage SL, Benedict AL, Min C, Dinkova-Kostova AT.

"Sulforaphane suppresses ultraviolet B-induced inflammation in HaCaT keratinocytes and HR-1 hairless mice." J Nutr Biochem. 2009 Jul 1. Shibata A, Nakagawa K, Yamanoi H, Tsuduki T, Sookwong P, Higuchi O, Kimura F, Miyazawa T. Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.

 

"Sulforaphane but not ascorbigen, indole-3-carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture." Exp Dermatol. 2009 Jun 23. Wagner AE, Ernst I, Iori R, Desel C, Rimbach G. Institute of Human Nutrition and Food Science, Christian-Albrechts-University, Kiel, Germany. Experimental Dermatology 2009.

Stomach Cancer - also see H. Pylori

"Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans." Cancer Prev Res (Phila Pa). 2009 Apr;2(4):353-60. Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, Zhang S, Tauchi M, Suzuki H, Hyodo I, Yamamoto M., Division of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba-Ken, Tokyo, Japan.

"Epidemiological studies on brassica vegetables and cancer risk." Cancer Epidemiol Biomarkers Prev. 1996 Sep;5(9):733-48. Verhoeven DT, Goldbohm RA, van Poppel G, Verhagen H, van den Brandt PA. Netherlands Organization for Applied Scientific Research, Nutrition and Food Research Institute, Zeist, The Netherlands.

"Role of glucoraphanin/sulfurophane from broccoli and broccoli sprouts in protection against cancer and other oxidative and degenerative diseases" 2005 IFT Annual Meeting, July 15-20 - New Orleans, Louisiana, Session 45, Health benefits of fruits and vegetables: Biological activity of phytonutrients, J. W. Fahey

 

"Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress." Inflammopharmacology. 2005;13(1):83-90. Yanaka A, Zhang S, Tauchi M, Suzuki H, Shibahara T, Matsui H, Nakahara A, Tanaka N, Yamamoto M.

Thyroid Cancer

"Phytoestrogens and Thyroid Cancer Risk: The San Francisco Bay Area Thyroid Cancer Study." Cancer Epidemiol Biomarkers Prev 2002 Jan;11(1):43-9, Horn-Ross PL, Hoggatt KJ, Lee MM. Northern California Cancer Center, 32960 Alvarado-Niles Road, Suite 600, Union City, CA 94587, USA.

Cardiovascular Disease - Also see Arteriolosclerosis, Blood Pressure, Cholesterol, Coronary Artery Disease Heart Disease and Hypertension

"Content and Composition of Isoflavonoids in Mature or Immature Beans and Bean Sprouts Consumed in Japan",  Journal of Health Science, 47(4) 394–406 (2001), Yumiko Nakamura,* Akiko Kaihara, Kimihiko Yoshii, Yukari Tsumura, Susumu Ishimitsu, and Yasuhide Tonogai, Division of Food Chemistry, National Institute of Health Sciences, Osaka Branch, 1–1–43 Hoenzaka, Chuo-ku, Osaka 540– 0006, Japan.

 

Dietary histone deacetylase inhibitors: From cells to mice to man. Semin Cancer Biol. 2007 May 5; Dashwood RH, Ho E. Linus Pauling Institute, Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.

"Folacin content of alfalfa and mung bean sprouts: The effect of extraction procedures and maturity" Journal of the Science of Food and Agriculture, Volume 36, Issue 11, Date: November 1985, Pages: 1155-1160, Marilyn F. Magaram, Cynthia L. Stotts, Tung-Shan Chen, Christine H. Smith, Arlene J. Kirsch, Division of Food Science and Nutrition Department of Home Economics, California State University, Northridge, California 91330, USA.

"Health effects of phytoestrogens" Forum Nutr. 2005;(57):100-11. Branca F, Lorenzetti S. National Institute for Research on Food and Nutrition, Rome, Italy.

Cataracts

"Aging Reversibility: from Thymus Graft to Vegetable Extract Treatment - Application to Cure an Age-associated Pathology"  Biogerontology. 2005;6(4):245-53. Basso A, Rossolini G, Piantanelli A, Amici D, Calzuola I, Mancinelli L, Marsili V, Gianfranceschi GL

"Nutritional Relevance of Wheat Sprouts Containing High Levels of Organic Phosphates and Antioxidant Compounds", J Clin Gastroenterol. 2004 Jul;38(6 Suppl):S123-6., Marsili V, Calzuola I, Gianfranceschi GL., Dipartimento di Biologia Cellulare e Molecolare, Universita degli Studi di Perugia, Perugia, Italy.

Central Nervous System Disorders

"Sulforaphane suppresses LPS-induced inflammation in primary rat microglia." Inflamm Res. 2009 Nov 19. Brandenburg LO, Kipp M, Lucius R, Pufe T, Wruck CJ. Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.

Cirrhosis of the Liver - See Alcohol Induced Liver Disease

Choleresis

"Antioxidant and Choleretic Properties of Raphanus sativus L. Sprout (Kaiware Daikon) Extract" J Agric Food Chem. 2006 Dec, 27;54(26):9773-9778, Barillari J, Cervellati R, Costa S, Guerra MC, Speroni E, Utan A, Iori R.

Cholesterol

"Aqua-culture improved buckwheat sprouts with more abundant precious nutrients and hypolipidemic activity." Int J Food Sci Nutr. 2009 Jun 30:1-14. Peng CC, Chen KC, Yang YL, Lin LY, Peng RY.

"Alfalfa seeds: effects on cholesterol metabolism" Experientia. 1980 May 15;36(5):562-4. Malinow MR, McLaughlin P, Stafford C.

"Alfalfa saponins and alfalfa seeds. Dietary effects in cholesterol-fed rabbits"  Atherosclerosis, 1980 Nov;37(3):433-8. Malinow MR, McLaughlin P, Stafford C, Livingston AL, Kohler GO.

"Brewer's spent grain, serum lipids and fecal sterol excretion in human subjects with ileostomies." J Nutr. 1991 Jun;121(6):778-84. Zhang JX, Lundin E, Andersson H, Bosaeus I, Dahlgren S, Hallmans G, Stenling R, Aman P. Department of Pathology, University of Umea, Sweden.

"Differing effects of water-soluble and fat-soluble extracts from Japanese radish (Raphanus sativus) sprouts on carbohydrate and lipid metabolism in normal and streptozotocin-induced diabetic rats." J Nutr Sci Vitaminol (Tokyo). 2007 Jun;53(3):261-6. Taniguchi H, Muroi R, Kobayashi-Hattori K, Uda Y, Oishi Y, Takita T. Department of Nutrition, Food Science and Culinary Arts, Toita Women's College, 2-21 17 Shiba, Minato-ku, Tokyo 105-0014, Japan. 

"Folacin content of alfalfa and mung bean sprouts: The effect of extraction procedures and maturity" Journal of the Science of Food and Agriculture, Volume 36, Issue 11, Date: November 1985, Pages: 1155-1160, Marilyn F. Magaram, Cynthia L. Stotts, Tung-Shan Chen, Christine H. Smith, Arlene J. Kirsch, Division of Food Science and Nutrition Department of Home Economics, California State University, Northridge, California 91330, USA.

"Impact of some commonly used Egyptian diets on plasma lipids profiles of rats.", Z Ernahrungswiss 1993 Sep;32(3):229-36, Metwalli OM, al-Okbi SY, Abbas AE., Food Science and Nutrition Department, National Research Centre, Dokki, Cairo, Egypt.

"Optimization of Bioactive Compounds in Buckwheat Sprouts and Their Effect on Blood Cholesterol in Hamsters." J Agric Food Chem. 2008 Jan 24, Lin LY, Peng CC, Yang YL, Peng RY.

"Phase 1 study of multiple biomarkers for metabolism and oxidative stress after one-week intake of broccoli sprouts" M Murashima, S Watanabe, XG Zhuo, M Uehara, and A Kurashige. Biofactors, January 1, 2004; 22(1-4): 271-5. The Department of Applied Bioscience, Tokyo University of Agriculture, 1-1-1, Sakuragaoka Setagaya, Tokyo, 156-8502, Japan.

"Plasma cholesterol-lowering effect on rats of dietary fiber extracted from immature plants.", Biosci Biotechnol Biochem 2000 Dec;64(12):2543-51, Nishimura N, Taniguchi Y, Kiriyama S., Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, Japan.

"Tartary buckwheat sprout powder lowers plasma cholesterol level in rats." J Nutr Sci Vitaminol (Tokyo). 2008 Dec;53(6):501-7. Kuwabara T, Han KH, Hashimoto N, Yamauchi H, Shimada K, Sekikawa M, Fukushima M. The United Graduate School of Agriculture Sciences, Iwate University.

Cochlear Degeneration

"Molecular mechanisms underlying cochlear degeneration in the tubby mouse and the therapeutic effect of sulforaphane." Neurochem Int. 2009 Mar-Apr;54(3-4):172-9. Epub 2008 Dec 9. Kong L, Chen GD, Zhou X, McGinnis JF, Li F, Cao W. Department of Ophthalmology and Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, USA.

Coeliac Disease

"Coeliac Disease:Gliadin is a Good Substrate of Several Transglutaminases: Possible Implication in the Pathogenesis of Coeliac Disease". By: Sjöström, H.. Scandinavian, Journal of Gastroenterology, Jul 2002, Vol. 37 Issue 7, p812, 6p.

Cognition

Colitis

“A new prebiotic from germinated barley for nutraceutical treatment of ulcerative colitis” Bamba T, Kanauchi O, Andoh A, Fujiyama Y.. Journal of Gastroenterology and Hepatology. 2002;17(8):818-824.

[A case of steroid dependent ulcerative colitis (total colitis type) treated by combined use of germinated barley foodstuff][Article in Japanese]Nippon Shokakibyo Gakkai Zasshi. 2003 Apr;100(4):426-9. Saito S, Kondo K, Hamada T, Ichimori T, Tanaka T, Suzaki A, Miura H, Yamada H, Takazoe M. Department of Internal Medicine, Social Insurance Chuo General Hospital.

 

"Butyrate from bacterial fermentation of germinated barley foodstuff preserves intestinal barrier function in experimental colitis in the rat model" J Gastroenterol Hepatol. 1999 Sep;14(9):880-8. Kanauchi O, Iwanaga T, Mitsuyama K, Saiki T, Tsuruta O, Noguchi K, Toyonaga A., Applied Bioresearch Center, Corporate Research and Development Division, Kirin Brewery Co. Ltd, Gunma, Japan.

 

"The dietary combination of germinated barley foodstuff plus Clostridium butyricum suppresses the dextran sulfate sodium-induced experimental colitis in rats" Scand J Gastroenterol. 2000 Oct;35(10):1060-7, Araki Y, Fujiyama Y, Andoh A, Koyama S, Kanauchi O, Bamba T., Dept. of Internal Medicine, Nagahama Red Cross Hospital, Japan.

 

"Dietary fiber fraction of germinated barley foodstuff attenuated mucosal damage and diarrhea, and accelerated the repair of the colonic mucosa in an experimental colitis" J Gastroenterol Hepatol. 2001 Feb;16(2):160-8.Kanauchi O, Iwanaga T, Andoh A, Araki Y, Nakamura T, Mitsuyama K, Suzuki A, Hibi T, Bamba T. Applied Bioresearch Center, Corporate Research and Development Division, Kirin Brewery Co. Ltd, Takasaki, Gunma, Japan.

 

"Effects of germinated barley foodstuff on dextran sulfate sodium-induced colitis in rats" J Gastroenterol. 1998 Apr;33(2):179-88. Kanauchi O, Nakamura T, Agata K, Mitsuyama K, Iwanaga T. Applied Bioresearch Center, Corporate Research and Development Division, Kirin Brewery Co. Ltd., Takasaki, Gunma, Japan.

 

"Effects of germinated barley foodstuff on microflora and short chain fatty acid production in dextran sulfate sodium-induced colitis in rats" Biosci Biotechnol Biochem. 2000, Sep;64(9):1794-800 Araki Y, Andoh A, Koyama S, Fujiyama Y, Kanauchi O, Bamba T. Department of Internal Medicine, Nagahama Red Cross Hospital, Shiga, Japan.

 

"Evaluation of antigenicity of germinated barley foodstuff for the treatment of ulcerative colitis in a chronic murine colitis model" Int J Mol Med. 2001 Feb;7(2):143-7, Kanauchi O, Serizawa I, Matsumura T, Fukuda Y, Satomi M., Nutrient Food and Feed Division, Kirin Brewery Co. Ltd., 10-1-2 Shinkawa Chuo-ku, Tokyo 104-8288, Japan.

 

"Germinated barley foodstuff, a prebiotic product, ameliorates inflammation of colitis through modulation of the enteric environment." J Gastroenterol. 2003;38(2):134-41. Kanauchi O, Serizawa I, Araki Y, Suzuki A, Andoh A, Fujiyama Y, Mitsuyama K, Takaki K, Toyonaga A, Sata M, Bamba T. Nutrient Food and Feed Division, Kirin Brewery Co Ltd, 2-10-1 Shinkawa, Chuo-ku, Tokyo 104-8288, Japan.

"Germinated barley foodstuff exhibits different adsorption properties for hydrophilic versus hydrophobic bile acids" Digestion. 2001;64(4):248-54. Araki Y, Andoh A, Fujiyama Y, Kanauchi O, Takenaka K, Higuchi A, Bamba T.Department of Internal Medicine, Nagahama Red Cross Hospital, Nagahama, Japan.

"Germinated barley foodstuff feeding. A novel neutraceutical therapeutic strategy for ulcerative colitis", Digestion. 2001;63 Suppl 1:60-7, Kanauchi O, Iwanaga T, Mitsuyama K., Applied Bioresearch Center, Corporate Research and Development Division, Kirin Brewery Co. Ltd., Takasaki, Japan.

"Germinated Barley Foodstuff Prolongs Remission in Patients with Ulcerative Colitis", Int J Mol Med. 2004 May;13(5):643-7. Hanai H, Kanauchi O, Mitsuyama K, Andoh A, Takeuchi K, Takayuki I, Araki Y, Fujiyama Y, Toyonaga A, Sata M, Kojima A, Fukuda M, Bamba T.

"Germinated barley foodstuffs attenuate colonic mucosal damage and mucosal nuclear factor kappa B activity in a spontaneous colitis model" J Gastroenterol Hepatol. 1999 Dec;14(12):1173-9 Kanauchi O, Andoh A, Iwanaga T, Fujiyama Y, Mitsuyama K, Toyonaga A, Bamba T.  Applied Bioresearch Center, Corporate Research and Development Division, Kirin Brewery Co. Ltd, Gunma, Japan.

"Prebiotic treatment of experimental colitis with germinated barley foodstuff: a comparison with probiotic or antibiotic treatment" Int J Mol Med. 2002 Jan;9(1):65-70. Fukuda M, Kanauchi O, Araki Y, Andoh A, Mitsuyama K, Takagi K, Toyonaga A, Sata M, Fujiyama Y, Fukuoka M, Matsumoto Y, Bamba T. Pharmaceutical Division, Kirin Brewery Co. Ltd., Shibuya-ku, Tokyo 150-8011, Japan.

"Treatment of ulcerative colitis by feeding with germinated barley foodstuff: first report of a multicenter open control trial” Kanauchi O, Suga T, Tochihara M, et al.. Journal of Gastroenterology. 2002;37(Suppl 14):67-72.

"Treatment of Ulcerative Colitis Patients by Long-Term Administration of Germinated Barley Foodstuff: Multi-Center Open Trial",  Int J Mol Med. 2003 Nov;12(5):701-4. Kanauchi O, Mitsuyama K, Homma T, Takahama K, Fujiyama Y, Andoh A, Araki Y, Suga T, Hibi T, Naganuma M, Asakura H, Nakano H, Shimoyama T, Hida N, Haruma K, Koga H, Sata M, Tomiyasu N, Toyonaga A, Fukuda M, Kojima A, Bamba T., Nutrient Food & Feed Division, Kirin Brewery Co. Ltd., Tokyo 104-8288, Japan.

"Treatment of ulcerative colitis with germinated barley foodstuff feeding: a pilot study” Aliment Pharmacol Ther. 1998 Dec;12(12):1225-30. Mitsuyama K, Saiki T, Kanauchi O, Iwanaga T, Tomiyasu N, Nishiyama T, Tateishi H, Shirachi A, Ide M, Suzuki A, Noguchi K, Ikeda H, Toyonaga A, Sata M.

Constipation

"Germinated barley foodstuff improves constipation induced by loperamide in rats"  Biosci Biotechnol Biochem 1998 Sep;62(9):1788-90. Kanauchi O, Hitomi Y, Agata K, Nakamura T, Fushiki T. Applied Bioresearch Center, Corporate Research and Development Division Kirin Brewery Co. Ltd., Gunma, Japan.

 

"Germinated barley foodstuff increases fecal volume and butyrate production in humans" Int J Mol Med. 1998 Jun;1(6):937-41. Kanauchi O, Mitsuyama K, Saiki T, Fushikia T, Iwanaga T. Applied Bioresearch Center, Corporate Research and Development Division, Kirin Brewery Co. Ltd., Takasaki, Gunma 370-12, Japan.

"Germinated barley foodstuff increases fecal volume and butyrate production at relatively low doses and relieves constipation in humans" Int J Mol Med. 1998 Oct;2(4):445-450. Kanauchi O, Mitsuyama K, Saiki T, Nakamura T, Hitomi Y, Bamba T, Araki Y, Fujiyama Y. Applied Bioresearch Center, Corporate Research and Development Division, Kirin Brewery Co. Ltd., Takasaki, Gunma 370-1295, Japan.

"Mechanism for the increased defecation and jejunum mucosal protein content in rats by feeding germinated barley foodstuff" Biosci Biotechnol Biochem. 1997 Mar;61(3):443-8. Kanauchi O, Agata K, Fushiki T. Applied Bioresearch Center, Kirin Brewery Co., Ltd., Gunma, Japan.

Coronary Artery Disease

Diabetes

"Antidiabetic activity of Mung bean extracts in diabetic KK-Ay mice." J Agric Food Chem. 2008 Oct 8;56(19):8869-73. Epub 2008 Sep 4. Yao Y, Chen F, Wang M, Wang J, Ren G. Institute of Crop Science, Chinese Academy of Agricultural Sciences, No. 80 South Xueyuan Road, Haidian District, Beijing, People's Republic of China.

"Differing effects of water-soluble and fat-soluble extracts from Japanese radish (Raphanus sativus) sprouts on carbohydrate and lipid metabolism in normal and streptozotocin-induced diabetic rats." J Nutr Sci Vitaminol (Tokyo). 2007 Jun;53(3):261-6. Taniguchi H, Muroi R, Kobayashi-Hattori K, Uda Y, Oishi Y, Takita T. Department of Nutrition, Food Science and Culinary Arts, Toita Women's College, 2-21 17 Shiba, Minato-ku, Tokyo 105-0014, Japan. 

"The Effect of Pre-Germinated Brown Rice Intake on Blood Glucose and PAI-1 Levels in Streptozotocin-Induced Diabetic Rats",  Biosci Biotechnol Biochem. 2004 Feb;68(2):444-7.  Hagiwara H, Seki T, Ariga T.

"Effects of young barley leaf extract and antioxidative vitamins on LDL oxidation and free radical scavenging activities in type 2 diabetes." Diabetes Metab. 2002 Apr;28(2):107-14. Yu YM, Chang WC, Chang CT, Hsieh CL, Tsai CE.

"Improved health-relevant functionality in dark germinated Mucuna pruriens sprouts by elicitation with peptide and phytochemical elicitors." Bioresour Technol. 2009 Oct;100(19):4507-14. Epub 2009 May 19, Randhir R, Kwon YI, Shetty K.

"The inhibition effects against α-amylase of plant extracts" Institute of Food Technologists Annual Meeting, New Orleans, Jun 30, 2008. Gyu-Hee Lee, Woosong University, Daejeon, Republic of Korea; Yeun-Kook Jung, Woosong University, Daejeon, Republic of Korea; Kee-Hyuk Kim, Woosong University, Daejeon, Republic of Korea; Myung-Gon Shin, Woosong University, Daejeon, Republic of Korea.

"Soaked and germinated Glycine max (soybean seeds) is highly effective blood sugar regulator" Dr. Manju Pathak,  B-506, PMO Apartments, C-58/20,Sector-62, Noida-201301, India.

 

"Vanadium-enriched chickpea sprout ameliorated hyperglycemia and impaired memory in streptozotocin-induced diabetes rats." Biometals. 2008 Oct;21(5):563-70. Epub 2008 Apr 23, Mao X, Zhang L, Xia Q, Sun Z, Zhao X, Cai H, Yang X, Xia Z, Tang Y., Department of Physiology, Shandong University School of Medicine, Wenhua Xi Road, Jinan, Shandong 250012, People's Republic of China.

Diarrhea

"Butyrate from bacterial fermentation of germinated barley foodstuff preserves intestinal barrier function in experimental colitis in the rat model" J Gastroenterol Hepatol. 1999 Sep;14(9):880-8. Kanauchi O, Iwanaga T, Mitsuyama K, Saiki T, Tsuruta O, Noguchi K, Toyonaga A., Applied Bioresearch Center, Corporate Research and Development Division, Kirin Brewery Co. Ltd, Gunma, Japan.

"Effects of germinated barley foodstuff in preventing diarrhea and forming normal feces in ceco-colectomized rats" Biosci Biotechnol Biochem. 1998 Feb;62(2):366-8. Kanauchi O, Nakamura T, Agata K, Fushiki T, Hara H. Applied Bioresearch Center, Corporate Research and Development Division Kirin Brewery Co. Ltd., Gunma, Japan.

"Evaluation of antigenicity of germinated barley foodstuff for the treatment of ulcerative colitis in a chronic murine colitis model" Int J Mol Med. 2001 Feb;7(2):143-7, Kanauchi O, Serizawa I, Matsumura T, Fukuda Y, Satomi M., Nutrient Food and Feed Division, Kirin Brewery Co. Ltd., 10-1-2 Shinkawa Chuo-ku, Tokyo 104-8288, Japan.

"Germinated barley foodstuff improves constipation induced by loperamide in rats"  Biosci Biotechnol Biochem 1998 Sep;62(9):1788-90. Kanauchi O, Hitomi Y, Agata K, Nakamura T, Fushiki T. Applied Bioresearch Center, Corporate Research and Development Division Kirin Brewery Co. Ltd., Gunma, Japan.

"Preventive effect of germinated barley foodstuff on diarrhea induced by water-soluble dietary fiber in rats" Biosci Biotechnol Biochem. 1997 Mar;61(3):449-54. Kanauchi O, Nakamura T, Agata K, Fushiki T. Applied Bioresearch Center, Kirin Brewery Co., Ltd., Gunma, Japan.

"Preventive effects of germinated barley foodstuff on methotrexate-induced enteritis in rats" Int J Mol Med. 1998 Jun;1(6):961-6. Kanauchi O, Mitsuyama K, Saiki T, Agata K, Nakamura T, Iwanaga T.  Applied Bioresearch Center, Corporate Research and Development Division, Kirin Brewery Co. Ltd., Takasaki, Gunma 370-12, Japan.

Electrophilic Stress

"Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous sulforaphane in rat aortic smooth muscle cells: cytoprotection against oxidative and electrophilic stress." Cardiovasc Toxicol. 2008 Fall;8(3):115-25. Epub 2008 Jul 8. Zhu H, Jia Z, Strobl JS, Ehrich M, Misra HP, Li Y. Division of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center, Blacksburg, VA 24060, USA.

Estrogen/Menopause Control

[A study on isoflavones intake from soy foods and perimenstrual symptoms] [Article in Korean] Taehan Kanho Hakhoe Chi. 2007 Apr;37(3):276-85. Kim HW, Khil JM. Department of Nursing, College of Medicine, Kwandong University, Korea.

"Assessing phytoestrogen exposure in epidemiologic studies: development of a database (United States).", Cancer Causes Control 2000 Apr;11(4):289-98, Horn-Ross PL, Barnes S, Lee M, Coward L, Mandel JE, Koo J, John EM, Smith M., Northern California Cancer Center, Union City 94587, USA.

"Chemical components with health implications in wild and cultivated Mexican common bean seeds (Phaseolus vulgaris L.)"
J Agric Food Chem. 2006 Mar 22;54(6):2045-52. Diaz-Batalla L, Widholm JM, Fahey GC Jr, Castano-Tostado E, Paredes-Lopez O. Programa de Posgrado en Alimentos del Centro de la Republica, Facultad de Quimica, Universidad Autonoma de Queretaro, Queretaro, Qro. 76010, Mexico.

"Clover Sprouts and Menopause" A News Extract from the Annual Review of Nutrition, 17:353-381 1997, DIETARY PHYTOESTROGENS By Kurtzer MS, Xu X.

"Determination of lignans and isoflavonoids in human female plasma following dietary supplementation.", J Endocrinol 1994 Aug;142(2):251-9, Morton MS, Wilcox G, Wahlqvist ML, Griffiths K., Tenovus Cancer Research Centre, University of Wales College of Medicine, Heath Park, Cardiff, UK.

"Dietary phytoestrogens." Annu Rev Nutr 1997;17:353-81, Kurzer MS, Xu X., Department of Food Science and Nutrition, University of Minnesota, St. Paul 55108, USA.

"Evaluation of the estrogenic effects of legume extracts containing phytoestrogens." J Agric Food Chem. 2003 Apr 9;51(8):2193-9. Boue SM, Wiese TE, Nehls S, Burow ME, Elliott S, Carter-Wientjes CH, Shih BY, McLachlan JA, Cleveland TE. Agricultural Research Service, Southern Regional Research Center, U.S. Department of Agriculture, New Orleans, Louisiana 70179, USA.

"Food sources of phyto-oestrogens and their precursors in Europe", Br J Nutr. 2003 Jun;89 Suppl 1:S39-43. Fletcher RJ. Kellogg Company, Manchester, UK.

"Health effects of phytoestrogens" Forum Nutr. 2005;(57):100-11. Branca F, Lorenzetti S. National Institute for Research on Food and Nutrition, Rome, Italy.

"Membrane estrogen receptor-alpha-mediated nongenomic actions of phytoestrogens in GH3/B6/F10 pituitary tumor cells" J Mol Signal. 2009 Apr 28;4:2, Jeng YJ, Kochukov MY, Watson CS.

"Phytoestrogens and Thyroid Cancer Risk: The San Francisco Bay Area Thyroid Cancer Study." Cancer Epidemiol Biomarkers Prev 2002 Jan;11(1):43-9, Horn-Ross PL, Hoggatt KJ, Lee MM. Northern California Cancer Center, 32960 Alvarado-Niles Road, Suite 600, Union City, CA 94587, USA.

"Phytoestrogen content of foods--a compendium of literature values.", Nutr Cancer 1996;26(2):123-48. Reinli K, Block G., Public Health Nutrition Program, University of California at Berkeley 94720, USA.

"Regulation of estrogen receptor alpha expression in human breast cancer cells by sulforaphane." Ramirez MC, Singletary K. Department of Food Science and Human Nutrition, University of Illinois, Urbana, 61801, USA.

Flatulence

"Biochemical and nutritional studies of germinated soybean seeds", [Article in Spanish]Arch Latinoam Nutr 1985 Sep;35(3):480-90.

"Chemistry and technology of green gram (Vigna radiata [L.] Wilczek).", Crit Rev Food Sci Nutr 1986;25(1):73-105, Adsule RN, Kadam SS, Salunkhe DK.

Glioma

"Combination treatment with resveratrol and sulforaphane induces apoptosis in human U251 glioma cells." Jiang H, Shang X, Wu H, Huang G, Wang Y, Al-Holou S, Gautam SC, Chopp M. Neurochem Res. 2010 Jan;35(1):152-61. Epub 2009 Aug 15. Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA.

H. pylori, Ulcers and Gastritis

"Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans." Cancer Prev Res (Phila Pa). 2009 Apr;2(4):353-60. Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, Zhang S, Tauchi M, Suzuki H, Hyodo I, Yamamoto M., Division of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba-Ken, Tokyo, Japan.

[Effects of sulforaphane-rich broccoli sprouts on H. pylori-infected gastric mucosa], Nippon Rinsho. 2005 Nov;63 Suppl 11:582-6.}  [Article in Japanese], Yanaka A, Tauchi M, Yamamoto M., Department of Gastroenterology, Graduate School of Comprehensive Human Sciences, University of Tsukuba.

"Efficacy of Sulforaphane in Eradicating Helicobacter pylori in Human Gastric Xenografts Implanted in Nude Mice", Antimicrob Agents Chemother. 2003 Dec;47(12):3982-3984. Haristoy X, Angioi-Duprez K, Duprez A, Lozniewski A.

"Oral Broccoli Sprouts Eradicate Helicobacter Pylori Infection", The American Journal of Gastroenterology, Volume 98, Issue 9, Supplement 1 , September 2003, Page S57, Abstracts Submitted for the 68th Annual Scientific Meeting of the American College of Gastroenterology, Mark V. Galan, M.D., Arfana A. Kishan, M.D.,  Ann L. Silverman, M.D.*. William Beaumont Hospital, Royal Oak, MI.

"Phytoceuticals: mighty but ignored weapons against Helicobacter pylori infection" Lee SY, Shin YW, Hahm KB. J Dig Dis. 2008 Aug;9(3):129-39. Review. Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.

 

"Role of glucoraphanin/sulfurophane from broccoli and broccoli sprouts in protection against cancer and other oxidative and degenerative diseases" 2005 IFT Annual Meeting, July 15-20 - New Orleans, Louisiana, Session 45, Health benefits of fruits and vegetables: Biological activity of phytonutrients, J. W. Fahey

 

"Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress." Inflammopharmacology. 2005;13(1):83-90. Yanaka A, Zhang S, Tauchi M, Suzuki H, Shibahara T, Matsui H, Nakahara A, Tanaka N, Yamamoto M.

"Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.", Proc Natl Acad Sci U S A 2002 May 28;99(11):7610-5, Fahey JW, Haristoy X, Dolan PM, Kensler TW, Scholtus I, Stephenson KK, Talalay P, Lozniewski A., Lewis B. and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205-2185, USA.

Heart Disease - also see Arteriolosclerosis, Blood Pressure, Cardiovascular Disease, Cholesterol, Coronary Artery Disease and Hypertension

"Dietary Approach to Attenuate Oxidative Stress, Hypertension, and Inflammation in the Cardiovascular System", Proceedings of the National Academy of Sciences of the United States of America, PNAS, May 4, 2004, vol. 101, no. 18, 7094-7099, Medical Sciences, Lingyun Wu , M. Hossein Noyan Ashraf*, Marina Facci, Rui Wang, Phyllis G. Paterson , Alison Ferrie and Bernhard H. J. Juurlink.

 

"Dietary phytoestrogens." Annu Rev Nutr 1997;17:353-81, Kurzer MS, Xu X., Department of Food Science and Nutrition, University of Minnesota, St. Paul 55108, USA.

Hyperglycemia

"Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease." Diabetes. 2008 Oct;57(10):2809-17. Epub 2008 Jul 15. Xue M, Qian Q, Adaikalakoteswari A, Rabbani N, Babaei-Jadidi R, Thornalley PJ. Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital, Coventry, UK.

Hypertension

Inflammation & Inflammatory Disorders

"Butyrate from bacterial fermentation of germinated barley foodstuff preserves intestinal barrier function in experimental colitis in the rat model" J Gastroenterol Hepatol. 1999 Sep;14(9):880-8. Kanauchi O, Iwanaga T, Mitsuyama K, Saiki T, Tsuruta O, Noguchi K, Toyonaga A., Applied Bioresearch Center, Corporate Research and Development Division, Kirin Brewery Co. Ltd, Gunma, Japan.

"Chemical Compositions and Antioxidant/Anti-inflammatory Activities of Steam Distillate from Freeze-Dried Onion (Allium cepa L.) Sprout." Takahashi M, Shibamoto T. J Agric Food Chem. 2008 Oct 23.

"Chemoprotection by sulforaphane: keep one eye beyond Keap1." Cancer Lett. 2006 Feb 28;233(2):208-18. Myzak MC, Dashwood RH. Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.

"Dietary Approach to Attenuate Oxidative Stress, Hypertension, and Inflammation in the Cardiovascular System", Proceedings of the National Academy of Sciences of the United States of America, PNAS, May 4, 2004, vol. 101, no. 18, 7094-7099, Medical Sciences, Lingyun Wu , M. Hossein Noyan Ashraf*, Marina Facci, Rui Wang, Phyllis G. Paterson , Alison Ferrie and Bernhard H. J. Juurlink.

"Dietary approach to decrease aging-related CNS inflammation" Nutr Neurosci. 2005 Apr;8(2):101-10.Noyan-Ashraf MH, Sadeghinejad Z, Juurlink BH.

"Dietary approaches to positively influence fetal determinants of adult health" FASEB J. 2005 Dec 14; Noyan-Ashraf MH, Wu L, Wang R, Juurlink BH.

"Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans." Cancer Prev Res (Phila Pa). 2009 Apr;2(4):353-60. Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, Zhang S, Tauchi M, Suzuki H, Hyodo I, Yamamoto M., Division of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba-Ken, Tokyo, Japan.

"Ethyl acetate extracts of alfalfa (Medicago sativa L.) sprouts inhibit lipopolysaccharide-induced inflammation in vitro and in vivo."  J Biomed Sci. 2009 Jul 14;16(1):64. Hong YH, Chao WW, Chen ML, Lin BF.

"Germinated barley foodstuff, a prebiotic product, ameliorates inflammation of colitis through modulation of the enteric environment." J Gastroenterol. 2003;38(2):134-41. Kanauchi O, Serizawa I, Araki Y, Suzuki A, Andoh A, Fujiyama Y, Mitsuyama K, Takaki K, Toyonaga A, Sata M, Bamba T. Nutrient Food and Feed Division, Kirin Brewery Co Ltd, 2-10-1 Shinkawa, Chuo-ku, Tokyo 104-8288, Japan.

"Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway" Clin Immunol. 2008 Nov 21. Riedl MA, Saxon A, Diaz-Sanchez D.  The Hart and Louis Laboratory, Clinical Immunology and Allergy, Department of Medicine, UCLA David Geffen School of Medicine.

 

"Sulforaphane inhibits TNF-alpha-induced activation of p38 MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells." Inflamm Res. 2009 Aug;58(8):513-21. Epub 2009 Mar 11.

Chen XL, Dodd G, Kunsch C. Discovery Research, AtheroGenics, Inc., 8995 Westside Parkway, Alpharetta, GA 30004, USA.

 

"Sulforaphane suppresses oligomerization of TLR4 in a thiol-dependent manner." Youn HS, Kim YS, Park ZY, Kim SY, Choi NY, Joung SM, Seo JA, Lim KM, Kwak MK, Hwang DH, Lee JY. J Immunol. 2010 Jan 1;184(1):411-9. Epub 2009 Nov 30. Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University, Asan, Korea.

 

"Sulforaphane suppresses ultraviolet B-induced inflammation in HaCaT keratinocytes and HR-1 hairless mice." J Nutr Biochem. 2009 Jul 1. Shibata A, Nakagawa K, Yamanoi H, Tsuduki T, Sookwong P, Higuchi O, Kimura F, Miyazawa T. Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.

Learning

"Effects of pre-germinated brown rice on beta-amyloid protein-induced learning and memory deficits in mice"  Biol Pharm Bull. 2004 Jul;27(7):1041-5. Mamiya T, Asanuma T, Kise M, Ito Y, Mizukuchi A, Aoto H, Ukai M. Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.

Macular Degeneration

Memory

"Effects of pre-germinated brown rice on beta-amyloid protein-induced learning and memory deficits in mice"  Biol Pharm Bull. 2004 Jul;27(7):1041-5. Mamiya T, Asanuma T, Kise M, Ito Y, Mizukuchi A, Aoto H, Ukai M. Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.

Menopause - See Estrogen

Menstruation, Premenstrual Symptoms, and Post Menstrual Symptoms - Also see Estrogen

[A study on isoflavones intake from soy foods and perimenstrual symptoms] [Article in Korean] Taehan Kanho Hakhoe Chi. 2007 Apr;37(3):276-85. Kim HW, Khil JM. Department of Nursing, College of Medicine, Kwandong University, Korea.

Muscle Damage

"Sulforaphane treatment protects skeletal muscle against damage induced by exhaustive exercise in rats." J Appl Physiol. 2009 Oct;107(4):1028-36. Epub 2009 Aug 27. Malaguti M, Angeloni C, Garatachea N, Baldini M, Leoncini E, Collado PS, Teti G, Falconi M, Gonzalez-Gallego J, Hrelia S. Dipartimento di Biochimica G. Moruzzi, Alma Mater Studiorum-Università di Bologna, Via Irnerio, 48, Bologna 40126, Italy.

Mutagenesis

"Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.", Proc Natl Acad Sci U S A 1997 Sep 16;94(19):10367-72, Fahey JW, Zhang Y, Talalay P. Brassica Chemoprotection Laboratory and Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Neurodegeneration

Dietary histone deacetylase inhibitors: From cells to mice to man. Semin Cancer Biol. 2007 May 5; Dashwood RH, Ho E. Linus Pauling Institute, Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.

"Health effects of phytoestrogens" Forum Nutr. 2005;(57):100-11. Branca F, Lorenzetti S. National Institute for Research on Food and Nutrition, Rome, Italy.

"Nrf2 activators provide neuroprotection against 6-hydroxydopamine toxicity in rat organotypic nigrostriatal cocultures." J Neurosci Res. 2009 May 15;87(7):1659-69.

Siebert A, Desai V, Chandrasekaran K, Fiskum G, Jafri MS. Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

Osteoporosis

"Dietary phytoestrogens." Annu Rev Nutr 1997;17:353-81, Kurzer MS, Xu X., Department of Food Science and Nutrition, University of Minnesota, St. Paul 55108, USA.

"Food sources of phyto-oestrogens and their precursors in Europe", Br J Nutr. 2003 Jun;89 Suppl 1:S39-43. Fletcher RJ. Kellogg Company, Manchester, UK.

"Health effects of phytoestrogens" Forum Nutr. 2005;(57):100-11. Branca F, Lorenzetti S. National Institute for Research on Food and Nutrition, Rome, Italy.

Oxidative Stress

Pathogenic Bacteria

"The antimicrobial effects of glucosinolates and their respective enzymatic hydrolysis products on bacteria isolated from the human intestinal tract." J Appl Microbiol. 2009 Jun;106(6):2086-95. Epub 2009 Mar 9. Aires A, Mota VR, Saavedra MJ, Rosa EA, Bennett RN. CITAB/UTAD-Centre for the Research and Technology for Agro-Environment and Biological Sciences, Integrative Biology and Quality group research, Universidade de Trás-os-Montes e Alto Douro, Apartado, Portugal.

Pregnancy

Respiratory Illness

"Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease." Am J Respir Crit Care Med. 2009 Jan 15;179(2):138-50. Epub 2008 Oct 17. Cho HY, Imani F, Miller-DeGraff L, Walters D, Melendi GA, Yamamoto M, Polack FP, Kleeberger SR. Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709, USA.

Retinal Light Damage (Eye damage from light)

"Sulforaphane Induces Thioredoxin through the Antioxidant-Responsive Element and Attenuates Retinal Light Damage in Mice"  Invest Ophthalmol Vis Sci. 2005 Mar;46(3):979-87. Tanito M, Masutani H, Kim YC, Nishikawa M, Ohira A, Yodoi J. Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, Japan

Retinal Degeneration

Rheumatoid Arthritis