Sprouts and Colon Cancer

Colon cancer is a serious health concern. Our archive of research contains all of the latest knowledge about the role sprouts play in combatting the disease.

"Activation of several concurrent proapoptic pathways by sulforaphane in human colon cancer cells SW620." Food Chem Toxicol. 2009 Sep;47(9):2366-73. Epub 2009 Jun 27. Rudolf E, Andelová H, Cervinka M. Department of Medical Biology and Genetics, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Simkova 870, Hradec Kralove, Czech Republic.

"Anti-Inflammatory Effect of Buckwheat Sprouts in Lipopolysaccharide-Activated Human Colon Cancer Cells and Mice" Biosci Biotechnol Biochem. 2008 Dec 7. Ishii S, Katsumura T, Shiozuka C, Ooyauchi K, Kawasaki K, Takigawa S, Fukushima T, Tokuji Y, Kinoshita M, Ohnishi M, Kawahara M, Ohba K. Department of Agricultural and Life Sciences, Obihiro University of Agriculture and Veterinary Medicine.

"Cancer-protective properties of high-selenium broccoli.", J Agric Food Chem 2001 May;49(5):2679-83, Finley JW, Ip C, Lisk DJ, Davis CD, Hintze KJ, Whanger PD., Grand Forks Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, P.O. Box 9034, Grand Forks, North Dakota 58203-9034, USA.

"Chemopreventive potential of canola and mustard on colon tumorigenesis in Fisher 344 male rats", Poster Sessions, Institute of Food Technologists, 525 West Van Buren, Suite 1000, Chicago, IL 60607, Jul 1 2008. Aretha Clisby, Martha Verghese, E. Cebert, Louis Shackelford, Lloyd T. Walker, Reuel Field, Judith Boateng, D. Williams, Venugopal Panala, David Asiamah, Rajitha Sunkara, Alabama A&M University, Normal, AL

"Cytotoxic and Antioxidant Activity of 4-Methylthio-3-butenyl Isothiocyanate from Raphanus sativus L. (Kaiware Daikon) Sprouts" J. Agric. Food Chem., 56 (3), 875-883, 2008. 10.1021/jf073123c.Alessio Papi, Marina Orlandi, Giovanna Bartolini, Jessica Barillari, Renato Iori, Moreno Paolini, Fiammetta Ferroni, Maria Grazia Fumo, Gian Franco Pedulli, and Luca Valgimigli.

Dietary histone deacetylase inhibitors: From cells to mice to man. Semin Cancer Biol. 2007 May 5; Dashwood RH, Ho E. Linus Pauling Institute, Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.

"Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention." J Nutr. 2009 Dec;139(12):2393-6. Epub 2009 Oct 7. Ho E, Clarke JD, Dashwood RH. Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis OR 97331, USA.

"Effect of Cruciferous and Leguminous Sprouts on Genotoxicity, in Vitro and in Vivo".Cancer Epidemiol Biomarkers Prev. 2004 Jul;13(7):1199-205. Gill CI, Haldar S, Porter S, Matthews S, Sullivan S, Coulter J, McGlynn H, Rowland I., Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, United Kingdom.

"Effect of vegetable and carotenoid consumption on aberrant crypt multiplicity, a surrogate end-point marker for colorectal cancer in azoxymethane-induced rats", Carcinogenesis, Vol. 20, No. 12, 2267-2272, December 1999, Philip J. Rijken, Wim G. Timmer, Aart J. van de Kooij, Ingrid M. van Benschop, Sheila A. Wiseman, Michiel Meijers and Lilian B.M. Tijburg, Unilever Research Vlaardingen, PO Box 114, 3130 AC, Vlaardingen, The Netherlands.

"Epidemiological studies on brassica vegetables and cancer risk." Cancer Epidemiol Biomarkers Prev. 1996 Sep;5(9):733-48. Verhoeven DT, Goldbohm RA, van Poppel G, Verhagen H, van den Brandt PA. Netherlands Organization for Applied Scientific Research, Nutrition and Food Research Institute, Zeist, The Netherlands.

"Evaluation of Nutritional Availability and Anti-Tumor Activity of Selenium Contained in Selenium-Enriched Kaiware Radish Sprouts"  Biosci Biotechnol Biochem. 2007 Sep 7;  Yoshida M, Okada T, Namikawa Y, Matsuzaki Y, Nishiyama T, Fukunaga K. Laboratory of Food and Nutritional Sciences, Department of Biotechnology, Faculty of Engineering, Kansai University.

"High-Selenium Broccoli Stymies Some Cancers", Science Update, Agricultural Research Magazine, April 2002.

"Increased growth of Bifidobacterium and Eubacterium by germinated barley foodstuff, accompanied by enhanced butyrate production in healthy volunteers" Int J Mol Med. 1999 Feb;3(2):175-9. Kanauchi O, Fujiyama Y, Mitsuyama K, Araki Y, Ishii T, Nakamura T, Hitomi Y, Agata K, Saiki T, Andoh A, Toyonaga A, Bamba T. Applied Bioresearch Center, Corporate Research and Development Division, Kirin Brewery Co. Ltd., Takasaki, Gunma 370-12, Japan.

"Inhibition of Autophagy Potentiates Sulforaphane-Induced Apoptosis in Human Colon Cancer Cells." Ann Surg Oncol. 2009 Oct 15. Nishikawa T, Tsuno NH, Okaji Y, Shuno Y, Sasaki K, Hongo K, Sunami E, Kitayama J, Takahashi K, Nagawa H. Department of Surgical Oncology, Faculty of Medical Science, The University of Tokyo, Tokyo, Japan.

"Kaiware Daikon (Raphanus sativus L.) extract: a naturally multipotent chemopreventive agent." J Agric Food Chem. 2008 Sep 10;56(17):7823-30. Epub 2008 Jul 30. Barillari J, Iori R, Papi A, Orlandi M, Bartolini G, Gabbanini S, Pedulli GF, Valgimigli L. Consiglio per la Ricerca e la Sperimentazione in Agricoltura, Centro di Ricerca per le Colture Industriali (CRA-CIN), via di Corticella 133, 4129 Bologna, Italy.

"Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds." Environ Mol Mutagen. 2009 Feb 5. Nian H, Delage B, Ho E, Dashwood RH. Linus Pauling Institute, Oregon State University, Corvallis, Oregon.

"Molecular Targets and Anticancer Potential of Indole-3-Carbinol and Its Derivatives" Cell Cycle. 2005 Sep 6;4(9), Aggarwal BB, Ichikawa H.

"Preventive Effects of Powdered Broccoli Sprout on Azoxymethane-induced Rat Colonic Aberrant Crypt Foci"  J Toxicol Pathol 2004; 17: 119-126Suzuki, Kohno, Sugie, Okada, and Tanaka.